Amplified Natural Killer Cell Activity and Attenuated Regulatory T-cell Function Are Determinants for Corneal Alloimmunity in Very Young Mice
Sign Up to like & getrecommendations! Published in 2022 at "Transplantation"
DOI: 10.1097/tp.0000000000004424
Abstract: Background. Corneal transplantation outcomes are generally less favorable in young children compared with adults. The purpose of this study was to determine the immunological mechanisms underlying this difference. Methods. A murine model of allogeneic corneal… read more here.
Keywords: young mice; cell; function; regulatory cell ... See more keywords
Age‐related deficits in neuronal physiology and cognitive function are recapitulated in young mice overexpressing the L‐type calcium channel, CaV1.3
Sign Up to like & getrecommendations! Published in 2023 at "Aging Cell"
DOI: 10.1111/acel.13781
Abstract: The calcium dysregulation hypothesis of brain aging posits that an age‐related increase in neuronal calcium concentration is responsible for alterations in a variety of cellular processes that ultimately result in learning and memory deficits in… read more here.
Keywords: young mice; calcium; age related; cav1 ... See more keywords
Aging exacerbates high-fat diet-induced steatohepatitis through alteration in hepatic lipid metabolism in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of gastroenterology and hepatology"
DOI: 10.1111/jgh.15006
Abstract: BACKGROUND AND AIM Aging is an independent risk factor for the progression of nonalcoholic steatohepatitis (NASH). Here we investigated the role of age-related alterations in fatty acid metabolism in dietary steatohepatitis using lipidomics analysis. METHODS… read more here.
Keywords: hfd; fat diet; elder mice; metabolism ... See more keywords
Obstructive sleep apnoea and susceptibility to cardiovascular disease: A blessing or curse of old age?
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DOI: 10.1111/resp.13679
Abstract: Obstructive sleep apnoea (OSA) is a common disorder affecting 25–30% of adults and is associated with cardiovascular morbidity and mortality. In some observational studies, older subjects appear to be protected against harmful OSA outcomes. For… read more here.
Keywords: age; study; old age; young mice ... See more keywords
Cytoplasmic mislocalization and mitochondrial colocalization of TDP-43 are common features between normal aged and young mice
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370220914253
Abstract: Transactive response DNA binding protein 43 (TDP-43) pathologies have been well recognized in various neurodegenerative disorders including frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS), and Alzheimer’s disease (AD). However, there have been limited studies… read more here.
Keywords: tdp; brain regions; young mice; normal aged ... See more keywords
Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation.
Sign Up to like & getrecommendations! Published in 2023 at "Blood"
DOI: 10.1182/blood.2022017514
Abstract: Hematopoietic stem cell (HSC) aging is accompanied by hematopoietic reconstitution dysfunction, including loss of regenerative and engraftment ability, myeloid differentiation bias and elevated risks of hematopoietic malignancies. Gut microbiota, a key regulator of host health… read more here.
Keywords: young mice; microbiota transplantation; fecal microbiota; hematopoietic stem ... See more keywords
Aging is associated with lower neuroactive steroids and worsened outcomes following cerebral ischemia in male mice.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac183
Abstract: Ischemic stroke is a leading cause of disability and death and aging is the main non-modifiable risk factor. Following ischemia, neuroactive steroids have been shown to play a key role in cerebroprotection. Thus, brain steroid… read more here.
Keywords: young mice; neuroactive steroids; brain; cerebral ischemia ... See more keywords
1941-P: Aging Disturbs the Inflammatory Balance in Adipose Tissue
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-1941-p
Abstract: Background: Aging (middle age) is usually associated with obesity and progressive low-grade inflammation in adipose tissue. However, how immune components in adipose tissue respond to aging is still not fully uncovered. Here, we sought to… read more here.
Keywords: compared young; aging mice; tissue; adipose tissue ... See more keywords
Protective effects of recombinant lactoferrin with different iron saturations on enteritis injury in young mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dairy science"
DOI: 10.3168/jds.2021-21428
Abstract: Infant intestinal development is immature and, thus, is vulnerable to bacterial and viral infections, which damage intestinal development and even induce acute enteritis. Numerous studies have investigated that lactoferrin (LF) has protective effects on the… read more here.
Keywords: young mice; protective effects; iron; group ... See more keywords
Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.1067493
Abstract: The ventral tegmental area (VTA) mediates incentive salience and reward prediction error through dopamine (DA) neurons that are regulated by local VTA GABA neurons. In young mice, VTA GABA cells exhibit a form of synaptic… read more here.
Keywords: young mice; depression; plasticity; cb1 ... See more keywords
Lactobacillus casei SYF-08 Protects Against Pb-Induced Injury in Young Mice by Regulating Bile Acid Metabolism and Increasing Pb Excretion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.914323
Abstract: Pb poisoning affects infant growth and development. However, dimercaptosuccinic acid (DMSA) as the current therapy for Pb poisoning exerts relatively significant toxic side effects in infants. Therefore, identifying a non-toxic treatment in this regard is… read more here.
Keywords: young mice; casei syf; lactobacillus casei; bile acid ... See more keywords