The Loss of YTHDC1 in Gut Macrophages Exacerbates Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205620
Abstract: The nuclear N6‐methyladenosine (m6A) reader YT521‐B homology‐domain‐containing protein 1 (YTHDC1) is required to maintain embryonic stem cell identity. However, little is known about its biological functions in intestinal‐resident macrophages and inflammatory bowel disease (IBD). Herein,… read more here.
Keywords: inflammatory bowel; ythdc1; bowel disease; loss ythdc1 ... See more keywords
m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1974175
Abstract: Dysregulation of macroautophagy/autophagy contributes to the delay of wound healing in diabetic skin. N6-methyladenosine (m6A) RNA modification is known to play a critical role in regulating autophagy. In this study, it was found that SQSTM1/p62… read more here.
Keywords: protein; diabetic skin; rna; autophagy ... See more keywords
YTHDC1 positively regulates PTEN expression and plays a critical role in cisplatin resistance of bladder cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13404
Abstract: Activation of PI3K/AKT signalling by PTEN loss significantly enhances chemoresistance in bladder cancer. This study aims to evaluate PTEN regulation and identify targets that could be used to relieve chemoresistance. Expression of YTHDC1, γ-H2AX and… read more here.
Keywords: cisplatin; bladder cancer; ythdc1; expression ... See more keywords
YTHDC1 Promotes Stemness Maintenance and Malignant Progression in Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells International"
DOI: 10.1155/2022/7494354
Abstract: Background YTH domain containing 1 (YTHDC1), an N6-methyladenosine (m6A) modification reading protein, plays a key role in regulating RNA translation and degradation. However, the role of YTHDC1 in head and neck squamous cell carcinoma (HNSCC)… read more here.
Keywords: cell; hnscc; ythdc1; stemness maintenance ... See more keywords
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity
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DOI: 10.1186/s12977-022-00589-1
Abstract: Background The recent discovery of the role of m 6 A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is… read more here.
Keywords: hiv; hiv rnas; ythdc1; infectivity ... See more keywords
Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007412
Abstract: The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3’ UTRs. Here we show that the nuclear m6A reader… read more here.
Keywords: reader ythdc1; nuclear m6a; m6a reader; m6a ... See more keywords