The m6A reader YTHDC2 inhibits lung adenocarcinoma tumorigenesis by suppressing SLC7A11-dependent antioxidant function
Sign Up to like & getrecommendations! Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101801
Abstract: The biological functions of N6-methyladenosine (m6A) RNA methylation are mainly dependent on the reader; however, its role in lung tumorigenesis remains unclear. Here, we have demonstrated that the m6A reader YT521-B homology domain containing 2… read more here.
Keywords: ythdc2; tumorigenesis; luad; m6a reader ... See more keywords
YTHDC2 promotes sepsis-induced cardiomyopathy by activating apoptosis and NF-κB pathway.
Sign Up to like & getrecommendations! Published in 2025 at "Virulence"
DOI: 10.1080/21505594.2025.2597565
Abstract: ABSTRACT Sepsis-induced cardiomyopathy (SICM) is a severe complication of sepsis, especially in children, and identification of novel therapeutic targets remains essential for improving patient outcomes. Recent studies have implicated N6-methyladenosine (m6A), an RNA epigenetic modification,… read more here.
Keywords: ythdc2; sepsis induced; induced cardiomyopathy; ythdc2 promotes ... See more keywords
The m6A reader YTHDC2 promotes the pathophysiology of temporal lobe epilepsy by modulating SLC7A11-dependent glutamate dysregulation in astrocytes
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DOI: 10.7150/thno.100703
Abstract: Rationale: Epilepsy affects over 70 million people globally, with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) often progressing to a drug-resistant state. Recent research has highlighted the role of reactive astrocytes and glutamate dysregulation in… read more here.
Keywords: xct; epilepsy; glutamate dysregulation; ythdc2 ... See more keywords