METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding
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DOI: 10.1038/s41467-021-23501-5
Abstract: The adenomatous polyposis coli (APC) is a frequently mutated tumour suppressor gene in cancers. However, whether APC is regulated at the epitranscriptomic level remains elusive. In this study, we analysed TCGA data and separated 200… read more here.
Keywords: apc mrna; ythdf; apc expression; mettl3 ... See more keywords
Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling
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DOI: 10.1128/mbio.00116-21
Abstract: It is believed that ∼7,000 messenger RNAs (mRNAs) are subject to N6-methyladenosine modification. The biological significance of this remains mysterious. ABSTRACT Enteroviruses (EV) deploy two proteases that mediate viral polyprotein cleavage and host cell manipulation.… read more here.
Keywords: cleavage; stat signaling; m6a readers; m6a ... See more keywords