Modulation of gene expression by YTH domain family (YTHDF) proteins in human physiology and pathology
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30907
Abstract: The advent of high throughput techniques in the past decade has significantly advanced the field of epitranscriptomics. The internal chemical modification of the target RNA at a specific site is a basic feature of epitranscriptomics… read more here.
Keywords: family; ythdf proteins; pathology; physiology ... See more keywords
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
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DOI: 10.1016/j.cell.2020.05.012
Abstract: N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a complex network of interactions between different m6A sites… read more here.
Keywords: ythdf proteins; m6a modified; unified model; m6a ... See more keywords
Structural and Dynamic Insights into Redundant Function of YTHDF Proteins
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DOI: 10.1021/acs.jcim.0c01029
Abstract: Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N6-methyladenosine (m6A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m6A-containing RNA using… read more here.
Keywords: ythdf proteins; insights redundant; structural dynamic; redundant function ... See more keywords
m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs
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DOI: 10.1093/nar/gkac251
Abstract: Abstract The transport of mRNAs to distal subcellular compartments is an important component of spatial gene expression control in neurons. However, the mechanisms that control mRNA localization in neurons are not completely understood. Here, we… read more here.
Keywords: localization; select neuronal; m6a ythdf; ythdf proteins ... See more keywords