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   Articles with "ythdf1" as a keyword



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m6A Reader YTHDF1‐Targeting Engineered Small Extracellular Vesicles for Gastric Cancer Therapy via Epigenetic and Immune Regulation

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recommendations! Published in 2022 at "Advanced Materials"

DOI: 10.1002/adma.202204910

Abstract: N6‐methyladenosine (m6A) modulators decide the fate of m6A‐modified transcripts and drive cancer development. RNA interference targeting m6A modulators promise to be an emerging cancer therapy but is challenging due to its poor tumor targeting and… read more here.

Keywords: cancer therapy; ythdf1; gastric cancer; m6a ... See more keywords
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N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer.

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recommendations! Published in 2021 at "Gastroenterology"

DOI: 10.1053/j.gastro.2021.12.269

Abstract: BACKGROUND & AIMS N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant m6A modifications and expression of m6A regulators. However, how m6A readers interpret oncogenic m6A methylome to promote… read more here.

Keywords: rhoa signaling; m6a; ythdf1; ythdf1 promotes ... See more keywords
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Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7)

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recommendations! Published in 2022 at "Bioengineered"

DOI: 10.1080/21655979.2022.2037381

Abstract: ABSTRACT N6-methyladenosine (m6A) is one of the most significant modifications in human mRNAs. Emerging evidence indicates that m6A participates in the initiation and development of malignant tumors. Nevertheless, the biological roles and mechanism of m6A… read more here.

Keywords: proliferation migration; migration invasion; ythdf1; level ... See more keywords

YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

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recommendations! Published in 2022 at "Journal of gastroenterology and hepatology"

DOI: 10.1111/jgh.15816

Abstract: BACKGROUND Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive disease with the underlying mechanisms poorly understood. YTHDF1, an m6 A reader protein, has important physiological functions in regulation of tumor development. However, the effect of YTHDF1… read more here.

Keywords: ythdf1 promotes; intrahepatic cholangiocarcinoma; ythdf1; icc ... See more keywords
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Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer

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recommendations! Published in 2023 at "Gut"

DOI: 10.1136/gutjnl-2022-328845

Abstract: Objective The role of N6-methyladenosine (m6A) in tumour immune microenvironment (TIME) remains understudied. Here, we elucidate function and mechanism of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in colorectal cancer (CRC) TIME. Design Clinical significance… read more here.

Keywords: time; seq; ythdf1; crc ... See more keywords
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Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells

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recommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2021-003663

Abstract: Background Gastric cancer (GC) is one of the most common cancer worldwide. We analyzed the expression of m6A regulatory genes in GC cohorts and revealed that YTHDF1 was uniquely upregulated in GC as compared with… read more here.

Keywords: loss ythdf1; antitumor immunity; loss; ythdf1 ... See more keywords
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YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7

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recommendations! Published in 2020 at "Cancer Research"

DOI: 10.1158/0008-5472.can-20-0066

Abstract: This study provides a rationale for controlling translation of key oncogenic drivers in cancer by manipulating epigenetic regulators, representing a novel and efficient strategy for anticancer treatment. N6-methyladenosine (m6A) is the most prevalent internal RNA… read more here.

Keywords: translation; fzd7; cancer; gastric cancer ... See more keywords
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The RNA m6A reader YTHDF1 is required for acute myeloid leukemia progression.

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recommendations! Published in 2023 at "Cancer research"

DOI: 10.1158/0008-5472.can-21-4249

Abstract: N6-methyladenosine (m6A), the most abundant modification in mRNAs, has been defined as a crucial modulator in the progression of acute myeloid leukemia (AML). Identification of the key regulators of m6A modifications in AML could provide… read more here.

Keywords: myeloid leukemia; progression; ythdf1; acute myeloid ... See more keywords
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Abstract 3716: RNA N6-methyladenosine binding protein, YTHDF1 regulates DNA repair and cancer immunity in protein synthesis levels

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recommendations! Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-3716

Abstract: N6-methyladenosine RNA methylation is one of the most abundant post transcriptional modifications in eukaryotic messenger RNAs and plays crucial roles in cancer development and progression. YTHDF1 is an m6A reader protein and has been reported… read more here.

Keywords: cancer immunity; ythdf1; protein; protein synthesis ... See more keywords
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Comprehensive Analysis of YTHDF1 Immune Infiltrates and ceRNA in Human Esophageal Carcinoma

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recommendations! Published in 2022 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2022.835265

Abstract: Background: YTHDF1 is highly expressed in multiple tumors and affects tumor progression. However, there are only a few comprehensive studies on the analysis of YTHDF1 in esophageal cancer. Methods: We analyzed YTHDF1 expression in pan-cancer… read more here.

Keywords: esophageal; ythdf1 expression; ythdf1; esca ... See more keywords
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YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma

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recommendations! Published in 2019 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2019.00332

Abstract: YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1) is a core factor in RNA methylation modification. Recent studies have shown that m6A is closely related to multiple tumors, thus YTHDF1 may also play a role… read more here.

Keywords: ythdf1; ythdf1 regulates; tumorigenicity; cancer ... See more keywords