N6-methyladenosine reader YTHDF1 promotes ARHGEF2 translation and RhoA signaling in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.12.269
Abstract: BACKGROUND & AIMS N6-methyladenosine (m6A) governs the fate of RNAs through m6A readers. Colorectal cancer (CRC) exhibits aberrant m6A modifications and expression of m6A regulators. However, how m6A readers interpret oncogenic m6A methylome to promote… read more here.
Keywords: rhoa signaling; m6a; ythdf1; ythdf1 promotes ... See more keywords
YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of gastroenterology and hepatology"
DOI: 10.1111/jgh.15816
Abstract: BACKGROUND Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive disease with the underlying mechanisms poorly understood. YTHDF1, an m6 A reader protein, has important physiological functions in regulation of tumor development. However, the effect of YTHDF1… read more here.
Keywords: ythdf1 promotes; intrahepatic cholangiocarcinoma; ythdf1; icc ... See more keywords