The m6 A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.
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DOI: 10.1002/advs.202101329
Abstract: Messenger RNA m6 A modification is shown to regulate local translation in axons. However, how the m6 A codes in axonal mRNAs are read and decoded by the m6 A reader proteins is still unknown.… read more here.
Keywords: local translation; parallel fiber; readers ythdf1; ythdf1 ythdf2 ... See more keywords
YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non–small-cell lung cancer
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DOI: 10.1080/2162402x.2021.1962656
Abstract: ABSTRACT The human YTH domain family (YTHDF) proteins are RNA-binding proteins that recognize N6-methyladenosine (m6A), facilitating various biological processes via m6A RNA modification. How these molecules associate with non–small-cell lung cancer (NSCLC) molecular mechanisms remain… read more here.
Keywords: ythdf1 ythdf2; tumor; lung cancer;
Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma
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DOI: 10.3389/fonc.2022.996634
Abstract: Background YTH domain-containing family protein 1 (YTHDF1) or YTHDF2 play crucial roles in cancer immunotherapy. We examine the expression of YTHDF1, YTHDF2, CD8, CD4, and FOXP3 to identify their prognostic or predictive role for PD-1/PD-L1… read more here.
Keywords: ythdf1 ythdf2; cell; ythdf1; expression ... See more keywords