METTL3 Mediates Epithelial-Mesenchymal Transition by Modulating FOXO1 mRNA N6 -Methyladenosine-Dependent YTHDF2 Binding: A Novel Mechanism of Radiation-Induced Lung Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202204784
Abstract: The biological roles of epithelial-mesenchymal transition (EMT) in the pathogenesis of radiation-induced lung injury (RILI) have been widely demonstrated, but the mechanisms involved have been incompletely elucidated. N6 -methyladenosine (m6 A) modification, the most abundant… read more here.
Keywords: ythdf2; modification; epithelial mesenchymal; radiation induced ... See more keywords
YTHDF2 interference suppresses the EMT of cervical cancer cells and enhances cisplatin chemosensitivity by regulating AXIN1
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.21942
Abstract: M6A reader YTH structural domain family 2 (YTHDF2) has been recognized to play an oncogenic role in numerous tumors, but its role in cervical cancer has not been extensively discussed yet. This paper was designed… read more here.
Keywords: cervical cancer; ythdf2; cisplatin chemosensitivity; cancer cells ... See more keywords
Binding to m6A RNA promotes YTHDF2-mediated phase separation
Sign Up to like & getrecommendations! Published in 2019 at "Protein & Cell"
DOI: 10.1007/s13238-019-00660-2
Abstract: As one of the most abundant modifications on mRNA in mammal, N-methyladenosine (mA) has been demonstrated to play important roles in various biological processes including nuclear RNA export, mRNA splicing, miRNA processing, mRNA degradation and… read more here.
Keywords: phase separation; ythdf2; rna; separation ... See more keywords
FTO regulates ocular angiogenesis via m6A-YTHDF2-dependent mechanism.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.108107
Abstract: Pathological ocular angiogenesis commonly results in visual impairment or even blindness. Unveiling the mechanisms of pathological angiogenesis is critical to identify the regulators and develop effective targeted therapies. Here, we used corneal neovascularization (CNV) model… read more here.
Keywords: angiogenesis; fto regulates; ythdf2; ocular angiogenesis ... See more keywords
Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway
Sign Up to like & getrecommendations! Published in 2020 at "Genes and Diseases"
DOI: 10.1016/j.gendis.2020.08.005
Abstract: Abstract Cellular senescence is closely associated with age-related diseases. Ovarian aging, a special type of organ senescence, is the pathophysiological foundation of the diseases of the reproductive system. It is characterized by the loss of… read more here.
Keywords: ythdf2 mapk; ythdf2; senescence; mapk pathway ... See more keywords
"Gamete On" for m6A: YTHDF2 Exerts Essential Functions in Female Fertility.
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DOI: 10.1016/j.molcel.2017.09.004
Abstract: In this issue of Molecular Cell, Ivanova et al. (2017) report key functions of the m6A reader YTHDF2 in the regulation of mammalian development during oocyte maturation and early zygotic development. read more here.
Keywords: gamete m6a; ythdf2; ythdf2 exerts; exerts essential ... See more keywords
YTHDF2 promotes multiple myeloma cell proliferation via STAT5A/MAP2K2/p-ERK axis
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DOI: 10.1038/s41388-022-02191-3
Abstract: Multiple myeloma (MM) is still incurable partially due to lacking effective therapeutic targets. Aberrant N6-methyladenosine (m6A) RNA modification plays a vital role in many cancers, however few researches are executed in MM. We first screened… read more here.
Keywords: cell proliferation; map2k2 erk; proliferation; map2k2 ... See more keywords
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion
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DOI: 10.1038/s41422-018-0072-0
Abstract: Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood (hUCB) holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number of HSCs in a single hUCB… read more here.
Keywords: hscs; expansion; ythdf2; stem cell ... See more keywords
m6A reader suppression bolsters HSC expansion
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DOI: 10.1038/s41422-018-0081-z
Abstract: The functional importance of N-methyladenosine (mA) modification in human health and disease has recently entered the research spotlight. In a recent paper published in Cell Research, Li et al. report a remarkable finding that deficiency… read more here.
Keywords: hscs; hsc expansion; ythdf2 knockout; expansion ... See more keywords
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells.
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DOI: 10.1158/2159-8290.cd-20-0331
Abstract: Glioblastoma is a universally lethal cancer driven by glioblastoma stem cells (GSCs). Here, we interrogated N6-methyladenosine (m6A) mRNA modifications in GSCs by methyl RNA-immunoprecipitation followed by sequencing (meRIP-seq) and transcriptome analysis, finding transcripts marked by… read more here.
Keywords: glioblastoma; m6a reader; stem cells; ythdf2 ... See more keywords
YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer
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DOI: 10.1186/s12943-020-01267-6
Abstract: Background N6-methyladenosine (m 6 A) is the most abundant modification in mRNA of humans. Emerging evidence has supported the fact that m 6 A is comprehensively involved in various diseases especially cancers. As a crucial… read more here.
Keywords: degradation; lhpp nkx3; ythdf2 mettl3; ythdf2 ... See more keywords