YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.10.004
Abstract: Brain metastasis is a major cause of cancer mortality, but its molecular mechanisms are severely understudied. In addition, little is known regarding the role of m6A reader YTHDF3 in human diseases. Here, we show that… read more here.
Keywords: m6a; ythdf3; brain metastasis; cancer ... See more keywords
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
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DOI: 10.1038/cr.2017.15
Abstract: N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs), and plays important roles in cell differentiation and tissue development. It regulates multiple steps throughout the RNA life cycle including RNA processing,… read more here.
Keywords: translation decay; ythdf3; m6a modified; translation ... See more keywords
Cytoplasmic m1A reader YTHDF3 inhibits trophoblast invasion by downregulation of m1A-methylated IGF1R
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DOI: 10.1038/s41421-020-0144-4
Abstract: N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of m1A-methylated messenger RNA (mRNA), but the “reader” protein and the exact biological role… read more here.
Keywords: m1a; invasion; reader; ythdf3 ... See more keywords
Abstract P5-01-16: m6A reader YTHDF3 promotes epithelial-mesenchymal transition and metastasis through facilitating Notch2 translation in breast cancer
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DOI: 10.1158/1557-3265.sabcs24-p5-01-16
Abstract: Breast cancer is a mammary epithelial tissues source tumor, the primary cause of death for breast cancer patients is distant metastasis. Epithelial-mesenchymal transition (EMT) is a crucial first step in the metastasis of the tumor.… read more here.
Keywords: cancer; breast cancer; ythdf3; tumor ... See more keywords
Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3
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DOI: 10.1186/s12943-019-1079-y
Abstract: BackgroundYAP activation is crucial for cancer development including colorectal cancer (CRC). Nevertheless, it remains unclear whether N6-Methyladenosine (m6A) modified transcripts of long noncoding RNAs (lncRNAs) can regulate YAP activation in cancer progression. We investigated the… read more here.
Keywords: gas5; ythdf3; yap; crc ... See more keywords
YTHDF3 regulates IL32 mRNA stability to promote osteogenic differentiation of bone mesenchymal stem cells in ankylosing spondylitis
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DOI: 10.1186/s12967-025-06607-y
Abstract: As a member of the family of the YTH domain and a an m6A reader, YTHDF3 is implicated in cancer and inflammatory diseases. However, its function in ankylosing spondylitis (AS)—a chronic inflammatory disease marked by… read more here.
Keywords: bone; stability; ythdf3; osteogenic differentiation ... See more keywords
YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.279739
Abstract: Hematopoietic stem cells (HSC) give rise to the cells of the blood system over the whole lifespan. N6-methyladenosine (m6A), the most prevalent RNA modification, modulates gene expression via the processes of “writing” and “reading”. Recent… read more here.
Keywords: modification; ythdf3; ccnd1; rna ... See more keywords
Integrated Clinical and Prognostic Analysis of the m6A RNA Methylation Regulator YTHDF3 in Pan-Cancer and its Correlation with Cancer Cell Proliferation
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DOI: 10.7150/jca.78403
Abstract: Background: N6-methyladenosine (m6A) is the most abundant and extensive chemical modification of mammalian RNA molecules. Although numerous studies have investigated m6A methylation-related genes, to the best of our knowledge, none have examined the expression patterns… read more here.
Keywords: ythdf3; proliferation; pan cancer; analysis ... See more keywords