Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.105771
Abstract: OBJECTIVE Intracerebral hemorrhage (ICH) is acknowledged as a serious clinical problem lacking effective treatments. And caspase-1-mediated inflammatory response happened during the progression of ICH. Therefore, we aimed to investigate the effects of caspase-1 inhibitor Ac-YVAD-cmk… read more here.
Keywords: caspase; yvad cmk; caspase mediated; intracerebral hemorrhage ... See more keywords
Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/6571676
Abstract: Caspase-1 is a proinflammatory caspase responsible for the proteolytic conversion of the precursor forms of interleukin-1β to its active form and plays an important role in the pathogenesis of various inflammatory diseases. It was reported… read more here.
Keywords: caspase; yvad cmk; induced nephrotoxicity; inhibition ... See more keywords