Homeostasis Imbalance of YY2 and YY1 Promotes Tumor Growth by Manipulating Ferroptosis.
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DOI: 10.1002/advs.202104836
Abstract: Ferroptosis is a type of programmed cell death caused by disruption of redox homeostasis and is closely linked to amino acid metabolism. Yin Yang 2 (YY2) and its homolog Yin Yang 1 (YY1) are highly… read more here.
Keywords: tumor; ferroptosis; yy2 yy1; yy1 ... See more keywords
Astrocytic Yin Yang 1 is critical for murine brain development and protection against apoptosis, oxidative stress, and inflammation
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DOI: 10.1002/glia.24286
Abstract: The transcription factor Yin Yang 1 (YY1) is ubiquitously expressed in mammalian cells, regulating the expression of a variety of genes involved in proliferation, differentiation, and apoptosis in a context‐dependent manner. While it is well‐established… read more here.
Keywords: apoptosis; yy1; oxidative stress; brain ... See more keywords
YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23105
Abstract: Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the… read more here.
Keywords: biogenesis; autophagy lysosomal; yy1 cooperates; biogenesis melanoma ... See more keywords
A critical role of transcription factor YY1 in rheumatoid arthritis by regulation of interleukin-6.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2016.10.008
Abstract: Previous studies have revealed a critical role of YY1, a "Yin Yang" transcription factor, in cancer development and progression. However, whether YY1 has any role in rheumatoid arthritis (RA) remains unknown. This study aims to… read more here.
Keywords: critical role; transcription factor; role; rheumatoid arthritis ... See more keywords
Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.04.009
Abstract: BACKGROUND The cardioprotective effects of metformin remain poorly defined. Interleukin (IL)-33/ST2L signaling is a novel cardioprotective pathway, which is antagonized by the soluble isoform sST2. No data exist about the regulation of ST2 expression. This… read more here.
Keywords: transcription factor; yy1; expression; cardiac remodeling ... See more keywords
Targeting ARNT to attenuate renal fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Nephrology"
DOI: 10.1038/s41581-018-0038-y
Abstract: © 2018 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature reviews | Nephrology Fibrosis is an important driver of end-stage organ failure and death in a variety of chronic diseases, including chronic… read more here.
Keywords: fk506; transcription; fibrosis; alk3 transcription ... See more keywords
Yin Yang 1 (YY1)-induced long intergenic non-protein coding RNA 472 (LINC00472) aggravates sepsis-associated cardiac dysfunction via the micro-RNA-335-3p (miR-335-3p)/Monoamine oxidase A (MAOA) cascade
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2017589
Abstract: ABSTRACT As a leading complication of sepsis, sepsis-induced cardiac dysfunction (SICD) contributed to the high mortality of patients with sepsis. Long non-coding RNA (LncRNA) LINC00472 has been reported to be in sepsis-induced disease. Nonetheless, its… read more here.
Keywords: yy1; cardiac dysfunction; mir 335; linc00472 ... See more keywords
YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins.
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DOI: 10.1089/cell.2017.0002
Abstract: Yinyang1 (YY1) participates in protein-DNA, protein-RNA, and protein-protein interactions and regulates developmental processes and disease mechanisms. YY1 interactions regulate a range of important biological functions, including oocyte maturation, epithelial to mesenchymal transition, and vascular endothelial… read more here.
Keywords: protein; oct4 sox2; sox2; yy1 ... See more keywords
O-GlcNAcylation of YY1 stimulates tumorigenesis in colorectal cancer cells by targeting SLC22A15 and AANAT.
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DOI: 10.1093/carcin/bgz010
Abstract: Emerging studies have revealed that O-GlcNAcylation plays pivotal roles in the tumorigenesis of colorectal cancers. However, the underlying mechanism still remains largely unknown. Here, we demonstrated that YY1 was O-GlcNAcylated by OGT and O-GlcNAcylation of… read more here.
Keywords: glcnacylation; tumorigenesis colorectal; glcnacylation yy1; slc22a15 aanat ... See more keywords
Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
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DOI: 10.1093/nar/gkab252
Abstract: Abstract Castration-resistant prostate cancer (CRPC) is a terminal disease and the molecular underpinnings of CRPC development need to be better understood in order to improve its treatment. Here, we report that a transcription factor Yin… read more here.
Keywords: brd2 pfkp; yy1 brd2; yy1; prostate cancer ... See more keywords
A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters
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DOI: 10.1093/nar/gkac233
Abstract: Abstract As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter connection. However, gaps still exist in understanding how YY1 coordinates coactivators and chromatin enhancer elements to assemble enhancers and super-enhancers. Here,… read more here.
Keywords: yy1; coactivators chromatin; histidine cluster; cluster ... See more keywords