The impact of bioceramic nanocarriers on the intranasal delivery of zaleplon nanoscale powder through new adsorption techniques: Improvement in bioavailability and hypnotic effect
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2019.101375
Abstract: Abstract The current work presents a new approach for nanosizing zaleplon (ZPN) powder aiming for enhancing its dissolution, bioavailability and hypnotic efficacy. Particles are adsorbed onto nanocarriers thereby acquiring their respective nanosizes. Nanoscale zaleplon was… read more here.
Keywords: bioavailability hypnotic; powder; new adsorption; zaleplon ... See more keywords
The potential of intranasal delivery of nanocrystals in powder form on the improvement of zaleplon performance: in-vitro, in-vivo assessment
Sign Up to like & getrecommendations! Published in 2021 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2021.1879834
Abstract: Abstract Objective The present work focuses on improving zaleplon (ZAP) performance through nanosizing its insoluble particles which were then delivered intranasally in powder form. Significance Since nanopowders have an exceptional ability to cross cell membrane,… read more here.
Keywords: powder form; intranasal delivery; form; performance ... See more keywords
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation
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DOI: 10.1080/10717544.2022.2115165
Abstract: Abstract Based on the administration convenience, transmucosal buccal drug delivery allows special strength points over peroral routes for systemic delivery. It could achieve local or systemic effect and boost drugs’ bioavailability for agents with first… read more here.
Keywords: lavender oil; lyophilized tablets; zaleplon; drug ... See more keywords