Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: The REALIZE study
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DOI: 10.3389/fonc.2022.900010
Abstract: Background A tenosynovial giant cell tumor (TGCT) is a locally aggressive benign neoplasm arising from intra- or extra-articular tissue, categorized as localized (L-TGCT, solitary lesion) and diffuse (D-TGCT, multiple lesions) TGCT. Surgical excision is the… read more here.
Keywords: zaltoprofen patients; zaltoprofen; placebo; group ... See more keywords
Population Pharmacokinetic Modeling of Zaltoprofen in Healthy Adults: Exploring the Dosage Regimen
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DOI: 10.3390/ph16020161
Abstract: Zaltoprofen is a drug used for various pain and inflammatory diseases. Scientific and quantitative dosage regimen studies regarding its clinical application are scarce. This study aimed to discover effective covariates related to interindividual pharmacokinetic variability… read more here.
Keywords: dosage regimen; population pharmacokinetic; pharmacokinetic modeling; zaltoprofen ... See more keywords
Design and Preparation of Zaltoprofen-Nicotinamide Pharmaceutical Cocrystals via Liquid Assisted Grinding Method
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DOI: 10.5530/ijper.53.4s.151
Abstract: Introduction: Pharmaceutical cocrystal is an endowed approach to augment solubility and dissolution of drugs with limited aqueous solubility. Zaltoprofen is a nonsteroidal anti-inflammatory drug with prevailing solubility problem. The present study deciphers preparation of cocrystals… read more here.
Keywords: assisted grinding; drug; zaltoprofen; solubility ... See more keywords