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Published in 2023 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1250
Abstract: Zanubrutinib is a second-generation Bruton tyrosine kinase inhibitor that is primarily metabolized by CYP3A enzymes. Previous drug-drug interaction (DDI) studies have demonstrated that co-administration of zanubrutinib with rifampin, a strong CYP3A inducer, reduces zanubrutinib plasma…
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Keywords:
open label;
zanubrutinib;
drug drug;
phase open ... See more keywords
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Published in 2023 at "Hematological oncology"
DOI: 10.1002/hon.3172
Abstract: Zanubrutinib has been approved for the treatment of patients with different lymphoproliferative disorders, and now represents a major breakthrough in the treatment of patients resistant or relapsing after the recommended therapies. Because few systematic studies…
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Keywords:
clinical needs;
use zanubrutinib;
zanubrutinib;
unmet clinical ... See more keywords
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Published in 2021 at "Expert Review of Clinical Pharmacology"
DOI: 10.1080/17512433.2021.1978288
Abstract: ABSTRACT Introduction: Bruton’s tyrosine kinase (BTK) inhibitors have revolutionized the treatment of B-cell lymphomas. Zanubrutinib was designed to achieve improved therapeutic concentrations and minimize off-target activities putatively accounting, in part, for the adverse effects seen…
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Keywords:
pharmacology;
zanubrutinib;
translation;
clinical pharmacology ... See more keywords
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Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18162
Abstract: This single‐arm, multicentre, phase I study is the first study of zanubrutinib, a potent, specific, irreversible Bruton tyrosine kinase (BTK) inhibitor, in Chinese patients with relapsed/refractory B‐cell malignancies. The objectives were to evaluate safety and…
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Keywords:
multicentre phase;
study zanubrutinib;
zanubrutinib;
single arm ... See more keywords
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Published in 2022 at "European Journal of Mass Spectrometry"
DOI: 10.1177/14690667221128934
Abstract: Zanubrutinib (BGB-3111) belongs to the class of irreversible inhibitors of Bruton's tyrosine kinase (BTK) for treating B-cell malignancies. A validated assay with excellent sensitivity, selectivity, and simplicity is required to measure plasma concentration and investigate…
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Keywords:
zanubrutinib;
mouse plasma;
zanubrutinib mouse;
quantitative evaluation ... See more keywords
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Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-122629
Abstract: Background: Bruton tyrosine kinase (BTK) plays a critical role in B-cell receptor signaling, which mediates B-cell proliferation, migration, and adhesion. Inhibition of BTK has emerged as a strategy for targeting B-cell malignancies including marginal zone…
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Keywords:
research;
zanubrutinib;
consultancy honoraria;
research funding ... See more keywords
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Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.8007
Abstract: 8007Background: Bruton tyrosine kinase (BTK) inhibition is an emerging standard of care for WM. ASPEN is a randomized phase 3 study comparing zanubrutinib (ZANU), a potent and selective BTK inhibit...
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Keywords:
results phase;
iii randomized;
phase iii;
zanubrutinib ... See more keywords
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Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.7553
Abstract: 7553 Background: Dual inhibition of PI3Kδ and BTK pathways may overcome existing or acquired monotherapy resistance. Dual inhibition of these pathways displays synergistic activity in cell lines that is evident even at suboptimal concentrations [Blood…
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Keywords:
combination;
cohort;
zanubrutinib;
cell ... See more keywords
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Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.22.00510
Abstract: PURPOSE Zanubrutinib is a potent, irreversible next-generation Bruton tyrosine kinase (BTK) inhibitor designed to maximize BTK occupancy and minimize off-target kinase inhibition. We hypothesized that complete/sustained BTK occupancy may improve efficacy outcomes and increased BTK…
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Keywords:
zanubrutinib versus;
interim analysis;
zanubrutinib;
versus ibrutinib ... See more keywords
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Published in 2022 at "Therapeutics and Clinical Risk Management"
DOI: 10.2147/tcrm.s338655
Abstract: Abstract In Waldenström macroglobulinemia (WM), a lymphoplasmacytic lymphoma characterized by monoclonal immunoglobulin M (IgM) gammopathy, aberrant Bruton tyrosine kinase (BTK) signaling has been identified as one mechanism of pathogenesis. For this reason, selective BTK inhibiting…
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Keywords:
waldenstr macroglobulinemia;
zanubrutinib;
zanubrutinib treating;
btk ... See more keywords
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Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1130595
Abstract: Zanubrutinib (BGB-3111, Brukinsa®, BeiGene) is a next-generation irreversible inhibitor of Bruton’s tyrosine kinase (BTK), developed by BeiGene in 2012 for the treatment of B-cell malignancies. It was designed to minimize off-target inhibition of TEC- and…
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Keywords:
safety;
zanubrutinib treatment;
lymphoid malignancies;
zanubrutinib ... See more keywords