Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2019.11.116
Abstract: Zinc-finger antiviral protein (ZAP) is a host antiviral factor that specifically restricts a wide range of viruses. ZAP selectively binds to CG-dinucleotide-enriched RNA sequences and recruits multiple RNA degradation machines to degrade target viral RNA.… read more here.
Keywords: zinc; rna; recognition; molecular mechanism ... See more keywords
ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study
Sign Up to like & getrecommendations! Published in 2018 at "Hematology, Transfusion and Cell Therapy"
DOI: 10.1016/j.htct.2018.03.008
Abstract: Background Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic… read more here.
Keywords: lymphocytic leukemia; central memory; chronic lymphocytic; zap ... See more keywords
A new susceptibility index to predict the risk of severe herpes zoster-associated pain: A Japanese regional population-based cohort study, the Shizuoka study.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2022.02.006
Abstract: BACKGROUND Approximately 7-20% of patients with herpes zoster (HZ) develop zoster-associated pain (ZAP). ZAP not only impairs quality of life and psychological well-being, but also can reduce work effectiveness, which has negative economic effects. Reports… read more here.
Keywords: risk; zap; study; index ... See more keywords
Interaction of Zap70 and CXCR4 receptor at lamellipodia that determines the directionality during Jurkat T cells chemotaxis.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular immunology"
DOI: 10.1016/j.molimm.2017.08.005
Abstract: Directional migration of T-lymphocytes is a key process during immune activation and is tightly regulated both temporally and spatially. The initial cell membrane protrusion at a particular site is critical for determining the direction of… read more here.
Keywords: lamellipodia; jurkat cells; jurkat; zap ... See more keywords
ZAP isoforms regulate unfolded protein response and epithelial- mesenchymal transition
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121453119
Abstract: Significance The human zinc finger antiviral protein ZAP potently restricts many important viruses such as SARS-CoV-2 and HIV. ZAP comes in two flavors, with a long and a short variant exhibiting slightly different functions that… read more here.
Keywords: zap; isoforms regulate; zap isoforms; regulate unfolded ... See more keywords
Inhibition of hepatitis E virus replication by zinc‐finger antiviral Protein synergizes with IFN‐β
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Viral Hepatitis"
DOI: 10.1111/jvh.13522
Abstract: Hepatitis E virus (HEV) infection is the most common cause of acute viral hepatitis worldwide. However, host–HEV interactions have yet to be fully understood. Zinc‐finger antiviral protein (ZAP) is a novel interferon (IFN)‐stimulated gene product… read more here.
Keywords: hev infection; hepatitis; hepatitis virus; zap ... See more keywords
ZAP, a CCCH-Type Zinc Finger Protein, Inhibits Porcine Reproductive and Respiratory Syndrome Virus Replication and Interacts with Viral Nsp9
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00001-19
Abstract: PRRSV continues to adversely impact the global swine industry. It is important to understand the various antiviral factors against PRRSV infection. Here, a zinc finger protein, termed ZAP, was screened from MAVS-induced antiviral genes by… read more here.
Keywords: prrsv infection; zap; zinc finger; zinc ... See more keywords
Characterization of Novel Splice Variants of Zinc Finger Antiviral Protein (ZAP)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00715-19
Abstract: ZAP is an IFN-induced host factor that can inhibit a wide range of viruses, and there is great interest in fully characterizing its antiviral mechanism. This is the first study that defines the antiviral capacities… read more here.
Keywords: expression; virus; zap; splice variants ... See more keywords
A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Virology"
DOI: 10.1128/jvi.00872-22
Abstract: The interferon system is part of the innate immune response that inhibits viruses and other pathogens. This system emerged approximately 500 million years ago in early vertebrates. ABSTRACT The zinc finger antiviral protein (ZAP) inhibits… read more here.
Keywords: zap; activity; zap emerged; khnyn ... See more keywords
The CCCH-Type Zinc Finger Antiviral Protein Relieves Immunosuppression of T Cells Induced by Avian Leukosis Virus Subgroup J via the NLP–PKC-δ–NFAT Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virology"
DOI: 10.1128/jvi.01344-21
Abstract: The evolution of the host defense system is driven synchronously in the process of resisting virus invasion. Accordingly, host innate defense factors effectively work to suppress virus replication. ABSTRACT The CCCH-type zinc finger antiviral protein… read more here.
Keywords: immunosuppression; virus; zap; pkc ... See more keywords
SAT0039 ZAP-70 CONTROLS AUTOIMMUNE ARTHRITIS VIA REGULATION OF APOPTOSIS THROUGH BCL-2, BIM AND CBL IN T CELLS
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.6910
Abstract: Background: The recombinant human G1(rhG1)-induced mouse arthritis (GIA) model resembles human rheumatoid arthritis in many aspects1. Similarly, to RA, GIA is also a T cell dependent disease: T cell activation and apoptosis has been shown… read more here.
Keywords: arthritis; apoptosis; autoimmune arthritis; mice ... See more keywords