SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2022.110331
Abstract: SYK and ZAP70 nonreceptor tyrosine kinases serve essential roles in initiating B-cell receptor (BCR) and T-cell receptor (TCR) signaling in B- and T-lymphocytes, respectively. Despite their structural and functional similarity, expression of SYK and ZAP70… read more here.
Keywords: autoimmunity lymphoid; zap70; syk zap70; zap70 kinases ... See more keywords
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05095-7
Abstract: Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear. Here we show that hypomorphic alleles of Zap70 or… read more here.
Keywords: arthritis; thymic differentiation; arthritis invariant; zap70 ... See more keywords
Dephosphorylation accelerates the dissociation of ZAP70 from the T cell receptor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116815119
Abstract: Significance Src homology 2 (SH2) domains are phosphotyrosine binding motifs that play key roles in cellular signaling. There are 110 proteins in the human genome containing SH2 binding domains, of which 10 contain tandem SH2… read more here.
Keywords: cell receptor; zap70; sh2 domains; sh2 ... See more keywords
Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1339847
Abstract: ABSTRACT In previous studies, we observed that Zeta-chain-associated protein kinase 70 (Zap70) regulates spindle assembly and chromosome alignment in mouse oocyte and that Ran binding protein 2 (RanBP2) is a highly associated gene with Zap70… read more here.
Keywords: ranbp2; cell cycle; exact timing; zap70 ... See more keywords
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
Sign Up to like & getrecommendations! Published in 2019 at "Science Signaling"
DOI: 10.1126/scisignal.aao0736
Abstract: “Alternative” ZAP70–dependent activation of the kinase p38 increases activation of the “classical” p38 cascade in T cells. Tipping the balance In T lymphocytes, the activity of the kinase p38 is required for the differentiation of… read more here.
Keywords: classical p38; kinase; p38; activation ... See more keywords
A disease-associated mutation that weakens ZAP70 autoinhibition enhances responses to weak and self-ligands
Sign Up to like & getrecommendations! Published in 2021 at "Science Signaling"
DOI: 10.1126/scisignal.abc4479
Abstract: Weakening autoinhibition of the kinase ZAP70 leads to overactive T cells and autoimmune disease. Stronger responses to weak ligands The protein tyrosine kinase ZAP70 links activated T cell antigen receptors (TCRs) to downstream signaling pathways.… read more here.
Keywords: responses weak; r360p mutation; zap70; cell ... See more keywords
CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03115
Abstract: The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule… read more here.
Keywords: molecule; ccr7; immunological synapse; zap70 ... See more keywords