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   Articles with "zbp1" as a keyword



TRIM56 Modulates YBX1 Degradation to Ameliorate ZBP1‐Mediated Neuronal PANoptosis in Spinal Cord Injury

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202407132

Abstract: Spinal cord injury (SCI) is a severe injury to the central nervous system, and its treatment is always a major medical challenge. Proinflammatory cell death is considered an important factor affecting neuroinflammation and the prognosis… read more here.

Keywords: degradation; panoptosis; injury; zbp1 ... See more keywords

The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202413675

Abstract: Angiostrongylus cantonensis (AC) is the leading cause of eosinophilic meningoencephalitis worldwide. The neuroimmune interactions between peripheral and central immune systems in angiostrongyliasis remain unclear. In this study, significant infiltration of eosinophils, myeloid cells, macrophages, neutrophils,… read more here.

Keywords: central nervous; nervous system; sensor; angiostrongylus cantonensis ... See more keywords
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Mechanism of β-actin mRNA Recognition by ZBP1

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recommendations! Published in 2017 at "Cell Reports"

DOI: 10.1016/j.celrep.2016.12.091

Abstract: Summary Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development. The high-resolution structures of… read more here.

Keywords: zbp1; actin mrna; recognition zbp1; mechanism actin ... See more keywords

ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-01963-2

Abstract: Local protein synthesis occurs in axons and dendrites of neurons, enabling fast and spatially restricted responses to a dynamically changing extracellular environment. Prior to local translation, mRNA that is to be translated is packed into… read more here.

Keywords: zbp1; hippocampal neurons; serine 181; transport ... See more keywords

Decoding the multiple functions of ZBP1 in the mechanism of sepsis-induced acute lung injury

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recommendations! Published in 2024 at "Communications Biology"

DOI: 10.1038/s42003-024-07072-x

Abstract: Sepsis-induced acute lung injury (ALI), characterized by severe hypoxemia and pulmonary leakage, remains a leading cause of mortality in intensive care units. The exacerbation of ALI during sepsis is largely attributed to uncontrolled inflammatory responses… read more here.

Keywords: induced acute; lung injury; sepsis induced; zbp1 ... See more keywords

Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2419620122

Abstract: Significance Coronaviruses can expertly evade our immune system. One way they do this is by employing the viral protein nsp15. This protein contains an endoribonuclease domain (EndoU), which cleaves viral RNA that would otherwise alert… read more here.

Keywords: endoribonuclease antagonizes; coronavirus endoribonuclease; antagonizes zbp1; zbp1 ... See more keywords

Z‐Nucleic Acid Sensing and Activation of ZBP1 in Cellular Physiology and Disease Pathogenesis

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recommendations! Published in 2025 at "Immunological Reviews"

DOI: 10.1111/imr.13437

Abstract: Z‐nucleic acid binding protein 1 (ZBP1) is an innate immune sensor recognizing nucleic acids in Z‐conformation. Upon Z‐nucleic acid sensing, ZBP1 triggers innate immune activation, inflammation, and programmed cell death during viral infections, mice development,… read more here.

Keywords: nucleic acid; physiology; activation; acid sensing ... See more keywords

Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1

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recommendations! Published in 2023 at "Science Signaling"

DOI: 10.1126/scisignal.abq0837

Abstract: Cellular stress granules arise in cells subjected to stress and promote cell survival. A cellular protein that localizes to stress granules is Z-DNA–binding protein 1 (ZBP1), which plays a major role in necroptosis, a programmed… read more here.

Keywords: stress granules; necroptosis; stress; binding protein ... See more keywords

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation

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recommendations! Published in 2022 at "mBio"

DOI: 10.1128/mbio.00401-22

Abstract: Influenza viruses cause respiratory tract infections, which lead to human disease outbreaks and pandemics. Influenza A virus (IAV) circulates in diverse animal species, predominantly aquatic birds. This often results in the emergence of novel viral… read more here.

Keywords: cell death; zbp1; virus; influenza virus ... See more keywords

Abstract 2920: ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in Ovarian cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-2920

Abstract: DNA double strand breaks (DSB) results in the accumulation of abnormal nucleic fragments in the cytosol, which activates nucleic acid sensors such as cGAS, DHX9, and AIM2, leading to innate immune responses. Intriguingly, these sensors… read more here.

Keywords: cancer; ovarian cancer; end resection; zbp1 ... See more keywords

Abstract 1052: Sex Specific Effects Of Zbp1 Deficiency In Mouse Lesion Necrotic Core

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recommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"

DOI: 10.1161/atvb.44.suppl_1.1052

Abstract: We previously fine mapped a mouse atherosclerosis susceptibility locus on chr 2 via an intercross between AKR/J (atherosclerosis resistant) and DBA/2J (atherosclerosis sensitive) strains on the apoE-deficient background. The Zbp1 gene, encoding Z-DNA binding protein… read more here.

Keywords: mice; area; lesion; atherosclerosis ... See more keywords