Mechanism of β-actin mRNA Recognition by ZBP1
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2016.12.091
Abstract: Summary Zipcode binding protein 1 (ZBP1) is an oncofetal RNA-binding protein that mediates the transport and local translation of β-actin mRNA by the KH3-KH4 di-domain, which is essential for neuronal development. The high-resolution structures of… read more here.
Keywords: zbp1; actin mrna; recognition zbp1; mechanism actin ... See more keywords
ZBP1 phosphorylation at serine 181 regulates its dendritic transport and the development of dendritic trees of hippocampal neurons
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01963-2
Abstract: Local protein synthesis occurs in axons and dendrites of neurons, enabling fast and spatially restricted responses to a dynamically changing extracellular environment. Prior to local translation, mRNA that is to be translated is packed into… read more here.
Keywords: zbp1; hippocampal neurons; serine 181; transport ... See more keywords
Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1
Sign Up to like & getrecommendations! Published in 2023 at "Science Signaling"
DOI: 10.1126/scisignal.abq0837
Abstract: Cellular stress granules arise in cells subjected to stress and promote cell survival. A cellular protein that localizes to stress granules is Z-DNA–binding protein 1 (ZBP1), which plays a major role in necroptosis, a programmed… read more here.
Keywords: stress granules; necroptosis; stress; binding protein ... See more keywords
Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.00401-22
Abstract: Influenza viruses cause respiratory tract infections, which lead to human disease outbreaks and pandemics. Influenza A virus (IAV) circulates in diverse animal species, predominantly aquatic birds. This often results in the emergence of novel viral… read more here.
Keywords: cell death; zbp1; virus; influenza virus ... See more keywords
ZBP1 Protects Against mtDNA-Induced Myocardial Inflammation in Failing Hearts
Sign Up to like & getrecommendations! Published in 2023 at "Circulation Research"
DOI: 10.1161/circresaha.122.322227
Abstract: Background: Mitochondrial DNA (mtDNA)-induced myocardial inflammation is intimately involved in cardiac remodeling. ZBP1 (Z-DNA binding protein 1) is a pattern recognition receptor positively regulating inflammation in response to mtDNA in inflammatory cells, fibroblasts, and endothelial… read more here.
Keywords: inflammation; mtdna induced; failing hearts; myocardial inflammation ... See more keywords
Human ZBP1 induces cell death‐independent inflammatory signaling via RIPK3 and RIPK1
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202255839
Abstract: ZBP1 is an interferon‐induced cytosolic nucleic acid sensor that facilitates antiviral responses via RIPK3. Although ZBP1‐mediated programmed cell death is widely described, whether and how it promotes inflammatory signaling is unclear. Here, we report a… read more here.
Keywords: cell death; inflammatory signaling; ripk3; zbp1 ... See more keywords
ZBP1 and heatstroke
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1091766
Abstract: Heatstroke, which is associated with circulatory failure and multiple organ dysfunction, is a heat stress-induced life-threatening condition characterized by a raised core body temperature and central nervous system dysfunction. As global warming continues to worsen,… read more here.
Keywords: heatstroke zbp1; zbp1; acid sensor; nucleic acid ... See more keywords
Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2019.02089
Abstract: West Nile virus (WNV), a neurotropic flavivirus, is the leading cause of viral encephalitis in the United States. Recently, Zika virus (ZIKV) infections have caused serious neurological diseases and birth defects, specifically Guillain-Barrè syndrome and… read more here.
Keywords: zbp1; infection; zikv; wnv ... See more keywords
ZBP1: A Powerful Innate Immune Sensor and Double-Edged Sword in Host Immunity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810224
Abstract: Z-conformation nucleic acid binding protein 1 (ZBP1), a powerful innate immune sensor, has been identified as the important signaling initiation factor in innate immune response and the multiple inflammatory cell death known as PANoptosis. The… read more here.
Keywords: zbp1 powerful; immunity; zbp1; zbp1 signaling ... See more keywords
Construction of ssDNA-Attached LR-Chimera Involving Z-DNA for ZBP1 Binding Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123706
Abstract: The binding of proteins to Z-DNA is hard to analyze, especially for short non-modified DNA, because it is easily transferred to B-DNA. Here, by the hybridization of a larger circular single-stranded DNA (ssDNA) with a… read more here.
Keywords: dna; chimera involving; ssdna; ssdna loop ... See more keywords