MicroRNA-520e suppresses non-small-cell lung cancer cell growth by targeting Zbtb7a-mediated Wnt signaling pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.02.121
Abstract: MicroRNAs (miRNAs) that negatively regulated gene expression have emerged as novel therapeutic target for non-small-cell lung cancer (NSCLC) treatment. In this study, we investigated the potential role of miR-520e and examined its functional role in… read more here.
Keywords: wnt signaling; cell growth; mir 520e; cell ... See more keywords
ZBTB7A links tumor metabolism to myeloid differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.05.010
Abstract: ZBTB7A is a transcription factor that regulates all three branches of hematopoietic differentiation while repressing the expression of key glycolytic enzymes and glucose transporters. Here, we propose that ZBTB7A acts as the link between differentiation… read more here.
Keywords: tumor metabolism; differentiation; links tumor; zbtb7a links ... See more keywords
Generation of a homozygous ZBTB7A knockout human induced pluripotent stem line by CRISPR/Cas9 editing.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell research"
DOI: 10.1016/j.scr.2021.102494
Abstract: ZBTB7A plays important roles in several biological processes, including silencing of the fetal γ-globin genes, hematopoiesis, primed-to-naive transition, etc. Meanwhile, it is also associated with Oncogenic transformation and tumor progression. However, the mechanism of ZBTB7A… read more here.
Keywords: knockout human; human induced; homozygous zbtb7a; stem ... See more keywords
ZBTB7A governs estrogen receptor alpha expression in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjy020
Abstract: ZBTB7A, a member of the POZ/BTB and Krüppel (POK) family of transcription factors, has been shown to have a context-dependent role in cancer development and progression. The role of ZBTB7A in estrogen receptor alpha (ERα)-positive… read more here.
Keywords: breast cancer; expression; cancer; estrogen receptor ... See more keywords
Zbtb7a induction in alveolar macrophages is implicated in anti-HLA–mediated lung allograft rejection
Sign Up to like & getrecommendations! Published in 2017 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aal1243
Abstract: Zbtb7a in alveolar macrophages influences early inflammation and autoimmunity in antibody-mediated rejection of transplanted lungs. Curbing culprits of chronic rejection De novo donor-specific antibodies generated after organ transplantation can lead to chronic rejection, and Nayak… read more here.
Keywords: alveolar macrophages; rejection; chronic rejection; induction ... See more keywords
Abstract 479: miR-372 enhances tumorigenesis and drug resistance in oral carcinoma by targeting ZBTB7A transcription factor
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-479
Abstract: miRNA-mediated post-transcriptional regulation of targeted genes plays crucial roles in neoplastic process. miR-372 has been shown an oncogenic miRNA which is hypoxia-inducible and is conspicuously up-regulated in oral squamous cell carcinoma (OSCC). Zinc finger and… read more here.
Keywords: mir 372; drug resistance; carcinoma; zbtb7a ... See more keywords
Abstract B057: ZBTB7A as a novel vulnerability in neuroendocrine prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b057
Abstract: Neuroendocrine prostate cancer (NEPC) is a lethal variant of aggressive prostate cancer. Hallmarks of NEPC include the loss of androgen receptor (AR) signaling and transdifferentiation toward small-cell neuroendocrine (SCN) phenotypes, which result in resistance to… read more here.
Keywords: cell; zbtb7a; prostate cancer; neuroendocrine prostate ... See more keywords
ZBTB7A functioned as an oncogene in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "BMC Gastroenterology"
DOI: 10.1186/s12876-020-01456-z
Abstract: Background Despite zinc finger and BTB domain-containing 7A (ZBTB7A) documented importance in multiple tumors, the function and clinical value in Colorectal cancer (CRC) remain elusive. The aim of this study was to evaluate the functional… read more here.
Keywords: colorectal cancer; functioned oncogene; crc patients; crc ... See more keywords