A palmitoyl transferase chemical–genetic system to map ZDHHC-specific S-acylation
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DOI: 10.1038/s41587-023-02030-0
Abstract: The 23 human zinc finger Asp-His-His-Cys motif-containing (ZDHHC) S-acyltransferases catalyze long-chain S-acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here we present a… read more here.
Keywords: palmitoyl transferase; acylation; zdhhc; genetic system ... See more keywords
Targeted degradation of zDHHC-PATs decreases substrate S-palmitoylation
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DOI: 10.1371/journal.pone.0299665
Abstract: Reversible S-palmitoylation of protein cysteines, catalysed by a family of integral membrane zDHHC-motif containing palmitoyl acyl transferases (zDHHC-PATs), controls the localisation, activity, and interactions of numerous integral and peripheral membrane proteins. There are compelling reasons… read more here.
Keywords: zdhhc; halo; degradation; substrate palmitoylation ... See more keywords