CCN3 secretion is regulated by palmitoylation via ZDHHC22.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.12.128
Abstract: Normal extracellular secretion of nephroblastoma overexpressed (NOV, also known as CCN3) is important for the adhesion, migration, and differentiation of cells. In previous studies, we have shown that the intracellular accumulation of CCN3 inhibits the… read more here.
Keywords: palmitoylation; secretion; zdhhc22; ccn3 secretion ... See more keywords
ZDHHC22-mediated mTOR palmitoylation restrains breast cancer growth and endocrine therapy resistance
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70544
Abstract: Palmitoylation is essential for the classic hallmarks of cancers through regulating protein stability and protein-protein interactions. ZDHHC22, as a well-known member of palmitoyltrans-ferase family, its role has not been revealed in cancer. We found ZDHHC22… read more here.
Keywords: breast cancer; palmitoylation; zdhhc22; endocrine therapy ... See more keywords