Synthetic Epigenetic Reprogramming of Mesenchymal to Epithelial States Using the CRISPR/dCas9 Platform in Triple Negative Breast Cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202301802
Abstract: Epithelial-mesenchymal transition (EMT) is a reversible transcriptional program invoked by cancer cells to drive cancer progression. Transcription factor ZEB1 is a master regulator of EMT, driving disease recurrence in poor-outcome triple negative breast cancers (TNBCs). Here,… read more here.
Keywords: breast; triple negative; dcas9; zeb1 ... See more keywords
Interplay Between Long Noncoding RNA ZEB1‐AS1 and miR‐200s Regulates Osteosarcoma Cell Proliferation and Migration
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25879
Abstract: In our previous study, we found long noncoding RNA ZEB1‐AS1 is upregulated and functions as an oncogene in osteosarcoma. MiR‐200 family (miR‐200s) functions as tumor suppressor via directly targeting ZEB1 in various cancers. In this… read more here.
Keywords: as1 mir; mir 200s; zeb1 as1; zeb1 ... See more keywords
Metformin inhibits tumorigenesis in HBV‐induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26555
Abstract: We aimed to understand whether metformin imposes the inhibitory effect on the HBV‐associated tumorigenesis by regulating the HULC and its downstream signaling pathway. Luciferase assay, RT‐PCR, and Western‐blot, MTT and flow cytometry analysis were performed… read more here.
Keywords: hulc; tumorigenesis; hbv; metformin ... See more keywords
LncRNA ZEB1-AS1/miR-409-3p/ZEB1 feedback loop is involved in the progression of non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.11.059
Abstract: Emerging evidence has illustrated that long noncoding RNA (LncRNA) ZEB1 antisense RNA 1 (ZEB1-AS1) involved in the development of various type of human cancers. However, the role of ZEB1-AS1 in non-small cell lung cancer (NSCLC)… read more here.
Keywords: mir 409; zeb1 as1; zeb1; lncrna zeb1 ... See more keywords
The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109588
Abstract: Summary Radial glia-like (RGL) stem cells persist in the adult mammalian hippocampus, where they generate new neurons and astrocytes throughout life. The process of adult neurogenesis is well documented, but cell-autonomous factors regulating neuronal and… read more here.
Keywords: transcription factor; cell; adult; zeb1 ... See more keywords
MicroRNA-708 represses hepatic stellate cells activation and proliferation by targeting ZEB1 through Wnt/β-catenin pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.172927
Abstract: Liver fibrosis is caused by a sustained wound healing response to chronic liver injury, and the activation of insubstantial hepatic stellate cells (HSCs) is the key process involved. The progression of liver fibrosis may be… read more here.
Keywords: zeb1; liver fibrosis; mir 708; activation proliferation ... See more keywords
Alterations in GRHL2-OVOL2-ZEB1 axis and aberrant activation of wnt signaling lead to altered gene transcription in posterior polymorphous corneal dystrophy.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107696
Abstract: Mutations associated with posterior polymorphous corneal dystrophy (PPCD) have been identified in three genes: ZEB1 (zinc-finger E-box binding homeobox 1) associated with sub-type PPCD3; OVOL2 (ovol-like zinc finger 2) associated with sub-type PPCD1; and GRHL2… read more here.
Keywords: corneal; wnt signaling; genetically unresolved; ppcd ... See more keywords
circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118082
Abstract: AIMS Hepatocellular carcinoma (HCC), one of the most common cancer, causes the fourth cancer-related deaths around the world. N6-methyladenosine (m6A) has been reported to mediate circRNA translation in cancer biology. However, the mechanisms by which… read more here.
Keywords: zeb1; circ kiaa1429; hcc; m6a ... See more keywords
Inhibition of long non-coding RNA MALAT1 elevates microRNA-429 to suppress the progression of hypopharyngeal squamous cell carcinoma by reducing ZEB1.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118480
Abstract: OBJECTIVE Hypopharyngeal squamous cell carcinoma (HSCC) is a common type of malignant tumor. Long non-coding RNAs (lncRNAs) are known to participate in HSCC development, while the role of lncRNA MALAT1 in HSCC remains largely unknown.… read more here.
Keywords: related proteins; mir 429; malat1; zeb1 ... See more keywords
A case of pulmonary pleomorphic carcinoma with malignant phenotypes induced by ZEB1-associated epithelial-mesenchymal transition
Sign Up to like & getrecommendations! Published in 2018 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2018.07.008
Abstract: A 60-year-old man was admitted to our hospital with non-small cell lung cancer (NSCLC). Imaging and pathological studies revealed NSCLC, not otherwise specified (NOS), at clinical stage T3N1M0 stage IIIA. We started radiotherapy alone because… read more here.
Keywords: zeb1; pleomorphic carcinoma; associated epithelial; epithelial mesenchymal ... See more keywords
ZEB1 protects skeletal muscle from damage and is required for its regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08983-8
Abstract: The mechanisms linking muscle injury and regeneration are not fully understood. Here we report an unexpected role for ZEB1 regulating inflammatory and repair responses in dystrophic and acutely injured muscles. ZEB1 is upregulated in the… read more here.
Keywords: muscle; regeneration; injured muscles; zeb1 ... See more keywords