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   Articles with "zeb2" as a keyword



Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer.

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recommendations! Published in 2018 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.01.036

Abstract: Growing evidence shows that lncRNA XIST functions as an oncogene accelerating tumor progression. Transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT) plays a key role in tumor metastasis. However, it is still unclear whether lncRNA… read more here.

Keywords: zeb2; xist; mir 367; tgf induced ... See more keywords

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

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recommendations! Published in 2018 at "Immunity"

DOI: 10.1016/j.immuni.2018.07.004

Abstract: SUMMARY Heterogeneity between different macrophage populations has become a defining feature of this lineage. However, the conserved factors defining macrophages remain largely unknown. The transcription factor ZEB2 is best described for its role in epithelial… read more here.

Keywords: identities macrophages; specific identities; zeb2; tissue specific ... See more keywords
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Mowat-Wilson syndrome: Generation of two human iPS cell lines (UUIGPi004A and UUIGPi005A) from siblings with a truncating ZEB2 gene variant.

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recommendations! Published in 2019 at "Stem cell research"

DOI: 10.1016/j.scr.2019.101518

Abstract: Mowat-Wilson syndrome (MWS) is a complex developmental syndrome caused by heterozygous mutations in the Zinc finger E-box-binding homeobox 2 gene (ZEB2). We generated the first human iPSC lines from primary fibroblasts of two siblings with… read more here.

Keywords: zeb2; cell; mowat wilson; ipsc lines ... See more keywords

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance

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recommendations! Published in 2019 at "Oncogenesis"

DOI: 10.1038/s41389-019-0125-3

Abstract: Colorectal cancer (CRC) patients develop recurrence after chemotherapy owing to the survival of stem cell-like cells referred to as cancer stem-like cells (CSCs). The origin of CSCs is linked to the epithelial–mesenchymal transition (EMT) process.… read more here.

Keywords: zeb2; cancer stem; colorectal cancer; cancer ... See more keywords

An Nfil3–Zeb2–Id2 pathway imposes Irf8 enhancer switching during cDC1 development

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recommendations! Published in 2019 at "Nature immunology"

DOI: 10.1038/s41590-019-0449-3

Abstract: Classical type 1 dendritic cells (cDC1s) are required for antiviral and antitumor immunity, which necessitates an understanding of their development. Development of the cDC1 progenitor requires an E-protein-dependent enhancer located 41 kilobases downstream of the transcription… read more here.

Keywords: enhancer; zeb2; cdc1 development; development ... See more keywords

Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular similarity between Mowat-Wilson syndrome and Ehlers-Danlos syndrome

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep46565

Abstract: Mowat-Wilson syndrome (MOWS) is a congenital disease caused by de novo heterozygous loss of function mutations or deletions of the ZEB2 gene. MOWS patients show multiple anomalies including intellectual disability, a distinctive facial appearance, microcephaly,… read more here.

Keywords: collagen; zeb2; mowat wilson; wilson syndrome ... See more keywords

ZEB2 knockdown inhibits interleukin-1β-induced cartilage degradation and inflammatory response through the Wnt/β-catenin pathway in human chondrocytes

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recommendations! Published in 2024 at "Scandinavian Journal of Rheumatology"

DOI: 10.1080/03009742.2024.2358594

Abstract: Objective Osteoarthritis (OA) is a degenerative disease of the joints characterized by inflammation and cartilage degeneration. Zinc finger E-box binding homeobox 2 (ZEB2) contains various function domains that interact with multiple transcription factors involved in… read more here.

Keywords: catenin pathway; zeb2; wnt catenin; cartilage ... See more keywords

Interaction between CASP8AP2 and ZEB2-CtBP2 Regulates the Expression of LEF1

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recommendations! Published in 2022 at "Pediatric Hematology and Oncology"

DOI: 10.1080/08880018.2022.2033369

Abstract: Abstract Low expression of CTBP2 and CASP8AP2 correlated with poor outcome and predicted risk of relapse in pediatric B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to investigate the molecular mechanism by which CASP8AP2 regulates… read more here.

Keywords: interaction; zeb2; expression; ctbp2 ... See more keywords

MicroRNA-142-3p facilitates inflammatory response by targeting ZEB2 and activating NF-κB signaling in gouty arthritis

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recommendations! Published in 2022 at "Cell Cycle"

DOI: 10.1080/15384101.2022.2031678

Abstract: ABSTRACT Gouty arthritis (GA) is caused by monosodium urate (MSU) crystal accumulation in the joints. MSU-mediated inflammation is an important inducing factor in gouty arthritis (GA). Recent studies have demonstrated that microRNAs can influence GA… read more here.

Keywords: mirna 142; inflammatory response; zeb2; gouty arthritis ... See more keywords

Comparing great apes reveals human-specific ZEB2 roles in neural development.

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recommendations! Published in 2025 at "Molecular biology and evolution"

DOI: 10.1093/molbev/msaf318

Abstract: Abstract Humans differ from other primates in various traits, despite nearly identical protein-coding sequences. Understanding the evolution of these differences requires studying transcriptional regulation. Here, we examine ZEB2, a transcription factor crucial for immune and… read more here.

Keywords: great apes; zeb2; neural development; human specific ... See more keywords

Long non-coding RNA HOTAIRM1 promotes proliferation and inhibits apoptosis of glioma cells by regulating the miR-873-5p/ZEB2 axis

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recommendations! Published in 2020 at "Chinese Medical Journal"

DOI: 10.1097/cm9.0000000000000615

Abstract: Abstract Background Glioblastoma is one of the most common malignant brain tumors. Conventional clinical treatment of glioblastoma is not sufficient, and the molecular mechanism underlying the initiation and development of this disease remains unclear. Our… read more here.

Keywords: expression; mir 873; glioblastoma; zeb2 ... See more keywords