Development of zebrafish demyelination model for evaluation of remyelination compounds and RORγt inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.106585
Abstract: RAR-related orphan receptor-γt (RORγt) directs differentiation of proinflammatory T helper 17 cells and is a potential therapeutic target for chronic autoimmune and inflammatory diseases including multiple sclerosis. In this study, zebrafish at days post fertilization… read more here.
Keywords: remyelination; zebrafish demyelination; demyelination model; myelin ... See more keywords
Small compounds mimicking the adhesion molecule L1 improve recovery in a zebrafish demyelination model
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85412-1
Abstract: Demyelination leads to a loss of neurons, which results in, among other consequences, a severe reduction in locomotor function, and underlies several diseases in humans including multiple sclerosis and polyneuropathies. Considerable clinical progress has been… read more here.
Keywords: adhesion molecule; demyelination; zebrafish demyelination; demyelination model ... See more keywords