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   Articles with "zebrafish embryo" as a keyword



Zebrafish Embryos Allow Prediction of Nanoparticle Circulation Times in Mice and Facilitate Quantification of Nanoparticle-Cell Interactions.

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recommendations! Published in 2020 at "Small"

DOI: 10.1002/smll.201906719

Abstract: The zebrafish embryo is a vertebrate well suited for visualizing nanoparticles at high resolution in live animals. Its optical transparency and genetic versatility allow noninvasive, real-time observations of vascular flow of nanoparticles and their interactions… read more here.

Keywords: circulation times; zebrafish embryo; nanoparticle; zebrafish embryos ... See more keywords

Deconvolving Passive and Active Targeting of Liposomes Bearing LDL Receptor Binding Peptides Using the Zebrafish Embryo Model.

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recommendations! Published in 2024 at "Small"

DOI: 10.1002/smll.202310781

Abstract: Improving target versus off-target ratio in nanomedicine remains a major challenge for increasing drug bioavailability and reducing toxicity. Active targeting using ligands on nanoparticle surfaces is a key approach but has limited clinical success. A… read more here.

Keywords: using zebrafish; receptor; zebrafish embryo; embryo model ... See more keywords
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Glyoxal Fixation as an Alternative for Zebrafish Embryo Immunostaining.

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recommendations! Published in 2021 at "Methods in molecular biology"

DOI: 10.1007/978-1-0716-0970-5_19

Abstract: Immunohistochemistry has been widely used as a robust technique to determine the cellular and subcellular localization of proteins. This information ultimately helps to understand the function of these proteins and how biological processes are regulated.… read more here.

Keywords: fixation alternative; fixation; zebrafish embryo; alternative zebrafish ... See more keywords
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Effective processing and evaluation of chemical imaging data with respect to morphological features of the zebrafish embryo

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recommendations! Published in 2021 at "Analytical and Bioanalytical Chemistry"

DOI: 10.1007/s00216-020-03131-4

Abstract: A workflow was developed and implemented in a software tool for the automated combination of spatially resolved laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) data and data on the morphology of the biological tissue. Making use… read more here.

Keywords: icp data; chemical imaging; zebrafish embryo; processing evaluation ... See more keywords

Place-based screening of mixtures of dominant emerging contaminants measured in Lake Michigan using zebrafish embryo gene expression assay.

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recommendations! Published in 2018 at "Chemosphere"

DOI: 10.1016/j.chemosphere.2017.11.043

Abstract: Determining impacts of emerging contaminants is difficult due to the different concentrations of mixtures of these chemicals over a landscape. Assessment approaches need to account for absorption, distribution, metabolism and excretion of the chemicals in… read more here.

Keywords: lake michigan; measured lake; emerging contaminants; zebrafish embryo ... See more keywords

Exposure to prothioconazole induces developmental toxicity and cardiovascular effects on zebrafish embryo.

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recommendations! Published in 2020 at "Chemosphere"

DOI: 10.1016/j.chemosphere.2020.126418

Abstract: Prothioconazole is a fungicide that has been widely used in general agriculture and livestock husbandry. This study evaluated the acute toxicity of prothioconazole to zebrafish embryos by assessing their hatching rate and malformation when exposed… read more here.

Keywords: zebrafish embryo; exposure; toxicity; rate ... See more keywords
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Lipidomics reveals multiple stressor effects (temperature × mitochondrial toxicant) in the zebrafish embryo toxicity test.

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recommendations! Published in 2020 at "Chemosphere"

DOI: 10.1016/j.chemosphere.2020.128472

Abstract: Aquatic organisms are exposed to multiple stressors in the environment, including contaminants and rising temperatures due to climate change. The objective of this study was to characterize the effect of increased temperature on chemical-induced toxicity… read more here.

Keywords: multiple stressor; temperature; zebrafish embryo; toxicity ... See more keywords

Promoting zebrafish embryo tool to identify the effects of chemicals in the context of Water Framework Directive monitoring and assessment

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recommendations! Published in 2019 at "Microchemical Journal"

DOI: 10.1016/j.microc.2019.104035

Abstract: Abstract The Water Framework Directive (WFD) addresses the European Union Member States to achieve a good status of all water bodies. The WFD measures have allowed to reduce and eliminate the discharges, releases, and emissions… read more here.

Keywords: framework directive; water; monitoring; water framework ... See more keywords

Leveraging Zebrafish Embryo Phenotypic Observations to Advance Data-Driven Analyses in Toxicology

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recommendations! Published in 2024 at "Environmental Science & Technology"

DOI: 10.1021/acs.est.4c11757

Abstract: Zebrafish have emerged as a central model organism in toxicological research. Zebrafish embryos are exempt from certain animal testing regulations which facilitates their use in toxicological testing. Next to the zebrafish embryo acute toxicity test… read more here.

Keywords: zebrafish embryo; phenotypic observations; toxicity; data driven ... See more keywords

Development a high-throughput zebrafish embryo acute toxicity testing method based on OECD TG 236

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recommendations! Published in 2022 at "Toxicology Mechanisms and Methods"

DOI: 10.1080/15376516.2022.2099772

Abstract: Abstract The Organization for Economic Co-operation and Development (OECD）Test Guideline (TG) 236 for zebrafish embryo acute toxicity testing was adopted for chemical toxicity assessment in 2013. Due to the increasing demand for prediction and evaluation… read more here.

Keywords: zebrafish embryo; toxicity testing; toxicity; acute toxicity ... See more keywords

A QSAR study for predicting malformation in zebrafish embryo

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recommendations! Published in 2024 at "Toxicology Mechanisms and Methods"

DOI: 10.1080/15376516.2024.2338907

Abstract: Abstract Background Developmental toxicity tests are extremely expensive, require a large number of animals, and are time-consuming. It is necessary to develop a new approach to simplify the analysis of developmental endpoints. One of these… read more here.

Keywords: zebrafish embryo; predicting malformation; malformation zebrafish; study predicting ... See more keywords