Zebrafish heart regenerates after chemoptogenetic cardiomyocyte depletion
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.305
Abstract: Zebrafish can regenerate adult cardiac tissue following injuries from ventricular apex amputation, cryoinjury, and cardiomyocyte genetic ablation. Here, we characterize cardiac regeneration from cardiomyocyte chemoptogenetic ablation caused by localized near‐infrared excited photosensitizer‐mediated reactive oxygen species… read more here.
Keywords: heart regenerates; regenerates chemoptogenetic; chemoptogenetic cardiomyocyte; cardiomyocyte depletion ... See more keywords
Complete primary structure of the I-band region of connectin at which mechanical property is modulated in zebrafish heart and skeletal muscle.
Sign Up to like & getrecommendations! Published in 2017 at "Gene"
DOI: 10.1016/j.gene.2016.10.010
Abstract: Connectin, also called titin, is the largest protein with a critical function as a molecular spring during contraction and relaxation of striated muscle; its mutation leads to severe myopathy and cardiomyopathy. To uncover the cause… read more here.
Keywords: zebrafish connectin; heart skeletal; structures zebrafish; zebrafish heart ... See more keywords
Reconstruction of regulatory network predicts transcription factors driving the dynamics of zebrafish heart regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146242
Abstract: The limited regenerative capacity in mammals has serious implications for cardiac tissue damage. Meanwhile, zebrafish has a high regenerative capacity, but the regulation of the heart healing process has yet to be elucidated. The dynamic… read more here.
Keywords: heart; zebrafish heart; state; regulatory network ... See more keywords
Genomics dissection of the zebrafish heart
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.402
Abstract: Development of the embryonic head is determined by the activity of gene regulatory networks (GRN) driven by transcription factors such as LHX1 and OTX2. Analysis of genetic mutants has revealed that loss of Lhx1 function… read more here.
Keywords: head; dissection zebrafish; lhx1; analysis ... See more keywords
Fate predetermination of cardiac myocytes during zebrafish heart regeneration
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170116
Abstract: Adult zebrafish have the remarkable ability to regenerate their heart upon injury, a process that involves limited dedifferentiation and proliferation of spared cardiomyocytes (CMs), and migration of their progeny. During regeneration, proliferating CMs are detected… read more here.
Keywords: heart; predetermination; regeneration; fate ... See more keywords
Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11060666
Abstract: The Alternative Reading Frame (ARF) protein is a tumor suppressor encoded by the Cyclin Dependent Kinase Inhibitor 2A gene in mammals but not lower regenerative vertebrates, and has been previously implicated as a context-sensitive suppressor… read more here.
Keywords: zebrafish heart; arf specifically; regeneration; epimorphic regeneration ... See more keywords