Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Hearing Research"
DOI: 10.1016/j.heares.2020.108019
Abstract: Abstract Hearing and balance deficits have been reported during and following treatment with the antimalarial drug chloroquine. However, experimental work examining the direct actions of chloroquine on mechanoreceptive hair cells in common experimental models is… read more here.
Keywords: lateral line; hair cells; hair; zebrafish lateral ... See more keywords
Activity regulates a cell type-specific mitochondrial phenotype in zebrafish lateral line hair cells
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.17.496604
Abstract: Hair cells of the inner ear are particularly sensitive to changes in mitochondria, the subcellular organelles necessary for energy production in all eukaryotic cells. There are over thirty mitochondrial deafness genes, and mitochondria are implicated… read more here.
Keywords: hair cell; mitochondrial phenotype; zebrafish lateral; hair cells ... See more keywords
Sirtuin 1 and Autophagy Attenuate Cisplatin-Induced Hair Cell Death in the Mouse Cochlea and Zebrafish Lateral Line
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00515
Abstract: Cisplatin-induced ototoxicity is one of the major adverse effects in cisplatin chemotherapy, and hearing protective approaches are unavailable in clinical practice. Recent work unveiled a critical role of autophagy in cell survival in various types… read more here.
Keywords: death; zebrafish lateral; autophagy; cell death ... See more keywords