Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of STXBP1 disorder
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia Open"
DOI: 10.1002/epi4.12604
Abstract: Objective CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient… read more here.
Keywords: antiseizure; clemizole trazodone; zebrafish model; effective antiseizure ... See more keywords
Novel mRNA therapy restores GALT protein and enzyme activity in a zebrafish model of classic galactosemia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12512
Abstract: Messenger RNA (mRNA) has emerged as a novel therapeutic approach for inborn errors of metabolism. Classic galactosemia (CG) is an inborn error of galactose metabolism caused by a severe deficiency of galactose‐1‐phosphate:uridylyltransferase (GALT) activity leading… read more here.
Keywords: enzyme activity; zebrafish model; activity; activity zebrafish ... See more keywords
A Zebrafish Model for Evaluating the Function of Human Leukemic Gene IDH1 and Its Mutation.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7142-8_13
Abstract: The recent advent of next-generation sequencing (NGS) has greatly accelerated identification of gene mutations in myeloid malignancies at unprecedented speed that will soon outpace their functional validation by conventional laboratory techniques and animal models. A… read more here.
Keywords: evaluating function; zebrafish model; model evaluating; model ... See more keywords
Necrostatin-1 Relieves Learning and Memory Deficits in a Zebrafish Model of Alzheimer's Disease Induced by Aluminum.
Sign Up to like & getrecommendations! Published in 2022 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00463-6
Abstract: Aluminum (Al) is considered one of the environmental risk factors for Alzheimer's disease (AD). The present study aims to establish a zebrafish AD model induced by Al and explore if necrostation-1 (Nec-1), a specific inhibitor… read more here.
Keywords: zebrafish model; memory deficits; learning memory; memory ... See more keywords
Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.071
Abstract: Bergapten (5-methoxypsoralen), a coumarin-derivate compound isolated from Ficus hirta roots, was evaluated for its anti-inflammatory and proresolution activities in a tail-cutting-induced zebrafish larvae model. Bergapten was evaluated using a caudal fin-wounded transgenic zebrafish line "Tg(corola:… read more here.
Keywords: anti inflammatory; proresolution activities; zebrafish model; model ... See more keywords
Gasdermin E mediates pyroptotic cell death of neutrophils and macrophages in a zebrafish model of chronic skin inflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Developmental and comparative immunology"
DOI: 10.1016/j.dci.2022.104404
Abstract: Chronic disease and hematopoietic disorders are associated with dysregulation of the inflammasome. Our group has recently reported the relevance of the inflammasome in the differentiation of hematopoietic stem and progenitor cells. However, the impact of… read more here.
Keywords: gasdermin; zebrafish model; skin inflammation; death ... See more keywords
Application and advantages of zebrafish model in the study of neurovascular unit.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174483
Abstract: The concept of "Neurovascular Unit" (NVU) was put forward, so that the research goal of Central Nervous System (CNS) diseases gradually transitioned from a single neuron to the structural and functional integrity of the NVU.… read more here.
Keywords: model; neurovascular unit; cns diseases; zebrafish model ... See more keywords
Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2019.01.008
Abstract: &NA; Acute hyperammonemic encephalopathy is a life‐threatening manifestation of individuals with urea cycle disorders, which is associated with high mortality rates and severe neurological sequelae in survivors. Cerebral bioenergetic failure has been proposed as one… read more here.
Keywords: hyperammonemia; dysfunction; zebrafish model; model acute ... See more keywords
New zebrafish model for monitoring proximal tubule physiology in genetic and acquired renal Fanconi syndromes.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.02.014
Abstract: Inherited and acquired disorders that affect proximal tubule endocytosis and lysosomal processing manifest with improper loss of solutes and proteins. The zebrafish pronephros is conserved with humans and is used to model numerous renal conditions,… read more here.
Keywords: zebrafish model; proximal tubule; model monitoring; physiology ... See more keywords
Short-term dietary restriction maintains synaptic plasticity whereas short-term overfeeding alters cellular dynamics in the aged brain: evidence from the zebrafish model organism
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.06.010
Abstract: Increased caloric intake (OF) impairs quality of life causing comorbidities with other diseases and cognitive deficits, whereas dietary restriction (DR) increases healthspan by preventing age-related deteriorations. To understand the effects of these opposing dietary regimens… read more here.
Keywords: term; zebrafish model; dietary restriction; short term ... See more keywords
A novel TLX1-driven T-ALL zebrafish model: comparative genomic analysis with other leukemia models
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-0938-2
Abstract: Zebrafish (Danio rerio) has become a well-established and powerful in vivo model to study the molecular basis of Tcell acute lymphoblastic leukemia (T-ALL) [1]. Langenau et al. [2] were the first to generate a cancer… read more here.
Keywords: phf6; zebrafish model; model; leukemia ... See more keywords