Zebrafish models of human eye and inner ear diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.10.006
Abstract: Eye and inner ear diseases are the most common sensory impairments that greatly impact quality of life. Zebrafish have been intensively employed to understand the fundamental mechanisms underlying eye and inner ear development. The zebrafish… read more here.
Keywords: inner ear; ear diseases; eye inner; models human ... See more keywords
Zebrafish models of leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.11.013
Abstract: The zebrafish, Danio rerio, is a well-established, invaluable model system for the study of human cancers. The genetic pathways that drive oncogenesis are highly conserved between zebrafish and humans, and multiple unique attributes of the… read more here.
Keywords: hematopoietic malignancies; model; zebrafish models; models leukemia ... See more keywords
Zebrafish models relevant to studying central opioid and endocannabinoid systems
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2018.03.024
Abstract: &NA; The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and… read more here.
Keywords: opioid systems; endocannabinoid opioid; systems zebrafish; model ... See more keywords
Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models
Sign Up to like & getrecommendations! Published in 2020 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.109873
Abstract: Drug abuse and brain disorders related to drug comsumption are public health problems with harmful individual and social consequences. The identification of therapeutic targets and precise pharmacological treatments to these neuropsychiatric conditions associated with drug… read more here.
Keywords: understanding neurobiological; drug; neurobiological effects; zebrafish models ... See more keywords
Dissecting metabolism using zebrafish models of disease.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20180335
Abstract: Zebrafish (Danio rerio) are becoming an increasingly powerful model organism to study the role of metabolism in disease. Since its inception, the zebrafish model has relied on unique attributes such as the transparency of embryos,… read more here.
Keywords: metabolism; models disease; using zebrafish; metabolism using ... See more keywords
Zebrafish models of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuac042
Abstract: Abstract Although COVID-19 has only recently appeared, research studies have already developed and implemented many animal models for deciphering the secrets of the disease and provided insights into the biology of SARS-CoV-2. However, there are… read more here.
Keywords: immunopathology; zebrafish models; model; models covid ... See more keywords
Zebrafish models of impulsivity and impulse control disorders
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14893
Abstract: Impulse control disorders (ICDs) are characterized by generalized difficulty controlling emotions and behaviors. ICDs are a broad group of the central nervous system (CNS) disorders including conduct disorder, intermittent explosive, oppositional‐defiant disorder, antisocial personality disorder,… read more here.
Keywords: control disorders; impulse control; zebrafish models; models impulsivity ... See more keywords
PO-214 Conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.732
Abstract: Introduction Melanoma is the most lethal type of skin cancer and its incidence continues to rise rapidly. While BRAFV600E inhibitors have led to significant improvements in outcomes for some patients, there are no targeted therapies… read more here.
Keywords: melanoma; mitf; regression; activity ... See more keywords
Use of zebrafish models to investigate rare human disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2018-105358
Abstract: Rare diseases are collectively common and often extremely debilitating. Following the emergence of next-generation sequencing (NGS) technologies, the variants underpinning rare genetic disorders are being unearthed at an accelerating rate. However, many rare conditions lack… read more here.
Keywords: large scale; rare diseases; disease; use zebrafish ... See more keywords
A hint from zebrafish models of hepatic tumorigenesis: Targeting stearoyl-CoA desaturase
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26645
Abstract: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death and is one of major regional diseases in China [1]. Given the decades of advancement in surgery, targeted drug, and immunotherapy, the overall survival… read more here.
Keywords: tumorigenesis; stearoyl coa; fatty acids; hepatic tumorigenesis ... See more keywords
Editorial: Zebrafish Models for Human Disease Studies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.861941
Abstract: Zebrafish are an attractive vertebrate model organism for biomedical discovery (Tavares and Santos Lopes, 2013). The advantages of using zebrafish are well known and include cost-effectiveness, high fecundity, short generation time, external development, transparency of… read more here.
Keywords: developmental biology; editorial zebrafish; disease; zebrafish models ... See more keywords