Zebularine protects against blood-brain-barrier (BBB) disruption through increasing the expression of zona occludens-1 (ZO-1) and vascular endothelial (VE)-cadherin
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DOI: 10.1080/21655979.2021.2024323
Abstract: ABSTRACT Blood-brain-barrier (BBB) disruption is an important pathological characteristic of ischemic stroke (IS) and mainly results from dysfunction of brain vascular endothelial cells and tight junctions. Zebularine is a novel inhibitor of DNA methyltransferase (DNMT).… read more here.
Keywords: zebularine; vascular endothelial; bbb disruption; blood brain ... See more keywords
The Protective Effect of Zebularine, an Inhibitor of DNA Methyltransferase, on Renal Tubulointerstitial Inflammation and Fibrosis
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DOI: 10.3390/ijms232214045
Abstract: Renal fibrosis, the final pathway of chronic kidney disease, is caused by genetic and epigenetic mechanisms. Although DNA methylation has drawn attention as a developing mechanism of renal fibrosis, its contribution to renal fibrosis has… read more here.
Keywords: zebularine; fibrosis; dna methyltransferase; inflammation fibrosis ... See more keywords