Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects.
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DOI: 10.1021/acs.jmedchem.2c00047
Abstract: Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that can change the expression of downstream target genes by catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3). Studies have found that EZH2… read more here.
Keywords: structure activity; activity relationships; treatment; zeste homolog ... See more keywords
Effect of enhancer of zeste homolog 2 mutations on the prognosis of patients with myelodysplastic syndrome
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DOI: 10.1097/md.0000000000021900
Abstract: Abstract Background: Gene mutations with important prognostic roles have been identified in patients with myelodysplastic syndrome (MDS). Overall, it is not yet fully clear whether enhancer of zeste homolog 2 (EZH2) is affected and contributes… read more here.
Keywords: patients myelodysplastic; zeste homolog; myelodysplastic syndrome; effect ... See more keywords
Epigenetic Modification of Enhancer of Zeste Homolog 2 Modulates the Activation of Dendritic Cells in Allergen Immunotherapy
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DOI: 10.1159/000500882
Abstract: Background: Allergen immunotherapy (AIT) is the only etiological and potentially curative therapy for allergic rhinitis (AR). Objectives: We sought to investigate the role of epigenetic regulator enhancer of zeste homolog 2 (EZH2) in the activation… read more here.
Keywords: epigenetic modification; allergen immunotherapy; zeste homolog; activation dendritic ... See more keywords
Enhancer of Zeste Homolog 2 (EZH2) Mediates Glucolipotoxicity-Induced Apoptosis in β-Cells
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DOI: 10.3390/ijms21218016
Abstract: Selective inhibition of histone deacetylase 3 (HDAC3) prevents glucolipotoxicity-induced β-cell dysfunction and apoptosis by alleviation of proapoptotic endoplasmic reticulum (ER) stress-signaling, but the precise molecular mechanisms of alleviation are unexplored. By unbiased microarray analysis of… read more here.
Keywords: glucolipotoxicity; apoptosis; zeste homolog; ezh2 ... See more keywords
GSK343, an Inhibitor of Enhancer of Zeste Homolog 2, Reduces Glioblastoma Progression through Inflammatory Process Modulation: Focus on Canonical and Non-Canonical NF-κB/IκBα Pathways
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DOI: 10.3390/ijms232213915
Abstract: Glioblastoma (GB) is a tumor of the central nervous system characterized by high proliferation and invasiveness. The standard treatment for GB includes radiotherapy and chemotherapy; however, new therapies are needed. Particular attention was given to… read more here.
Keywords: canonical non; canonical pathways; non canonical; immune response ... See more keywords