Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening.
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DOI: 10.1007/s11095-020-02895-9
Abstract: PURPOSE We characterized three canine P-gp (cP-gp) deficient MDCKII cell lines. Their relevance for identifying efflux transporter substrates and predicting limitation of brain penetration were evaluated. In addition, we discuss how compound selection can be… read more here.
Keywords: deficient; cell lines; brain penetration; cell ... See more keywords