Activation of the MKK3-p38-MK2-ZFP36 Axis by Coronavirus Infection Restricts the Upregulation of AU-Rich Element-Containing Transcripts in Proinflammatory Responses
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DOI: 10.1128/jvi.02086-21
Abstract: Excessive and uncontrolled induction and release of proinflammatory cytokines and chemokines, the so-called cytokine release syndrome (CRS), would cause life-threatening complications and multiple organ failure in severe coronavirus infections, including severe acute respiratory syndrome (SARS),… read more here.
Keywords: coronavirus; kinase; zfp36; coronavirus infection ... See more keywords
Abstract 4740: Loss of the tumor suppressor zinc finger protein-36 and risk of lethal prostate cancer
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DOI: 10.1158/1538-7445.am2017-4740
Abstract: Background. Biomarkers are needed to complement current clinicopathologic variables towards distinguishing prostate tumors that are likely to be metastatic from those that are indolent. We previously used a bioinformatic analytical approach to identify ZFP36, also… read more here.
Keywords: zfp36; tumor suppressor; prostate cancer; cancer ... See more keywords
Promoter Methylation Leads to Decreased ZFP36 Expression and Deregulated NLRP3 Inflammasome Activation in Psoriatic Fibroblasts
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DOI: 10.3389/fmed.2020.579383
Abstract: The mRNA-destabilizing protein tristetraprolin (TTP), encoded by the ZFP36 gene, is known to be able to end inflammatory responses by directly targeting and destabilizing mRNAs encoding pro-inflammatory cytokines. We analyzed its role in psoriasis, a… read more here.
Keywords: inflammasome activation; zfp36; psoriatic fibroblasts; expression ... See more keywords
ZFP36 RNA-binding proteins restrain T cell activation and anti-viral immunity
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DOI: 10.7554/elife.33057
Abstract: Dynamic post-transcriptional control of RNA expression by RNA-binding proteins (RBPs) is critical during immune response. ZFP36 RBPs are prominent inflammatory regulators linked to autoimmunity and cancer, but functions in adaptive immunity are less clear. We… read more here.
Keywords: immunity; zfp36; rna binding; cell activation ... See more keywords