Identification of deleterious non-synonymous single nucleotide polymorphisms in the mRNA decay activator ZFP36L2.
Sign Up to like & getrecommendations! Published in 2024 at "RNA biology"
DOI: 10.1080/15476286.2024.2437590
Abstract: ABSTRACT More than 4,000 single nucleotide polymorphisms (SNP) variants have been identified in the human ZFP36L2 gene, however only a few have been studied in the context of protein function. The tandem zinc finger domain… read more here.
Keywords: zfp36l2; single nucleotide; non synonymous; deleterious non ... See more keywords
A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical genetics"
DOI: 10.1111/cge.14362
Abstract: Normal oocyte maturation is an important requirement for the success of human reproduction, and defects in this process will lead to female infertility and repeated IVF/ICSI failures. In order to identify genetic factors that are… read more here.
Keywords: maturation; maturation defect; oocyte maturation; female infertility ... See more keywords
ZFP36L2 as a promising therapeutic target in acute graft-versus-host disease: Evidence from murine models and clinical validation
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DOI: 10.1182/blood-2025-5863
Abstract: Introduction Acute graft-versus-host disease (aGVHD) remains a major cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Dysfunctional regulatory T cells (Tregs) are implicated in aGVHD pathogenesis, but molecular mechanisms remain unclear. Emerging… read more here.
Keywords: agvhd; group; zfp36l2; target ... See more keywords
High expression of ZFP36L2 correlates with the prognosis and immune infiltration in lower-grade glioma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.914219
Abstract: Background: The ZFP36 Ring Finger Protein Like 2 (ZFP36L2) is an RNA-binding protein that regulates gene expression at post-transcriptional level. However, the clinical significance and prognostic value of ZFP36L2 in lower-grade glioma (LGG) remain unclear.… read more here.
Keywords: immune infiltration; grade glioma; expression; zfp36l2 ... See more keywords
ZFP36L2 Role in Thyroid Functionality
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179379
Abstract: Thyroid hormone levels are usually genetically determined. Thyrocytes produce a unique set of enzymes that are dedicated to thyroid hormone synthesis. While thyroid transcriptional regulation is well-characterized, post-transcriptional mechanisms have been less investigated. Here, we… read more here.
Keywords: role thyroid; zfp36l2 role; thyroid functionality; thyroid specific ... See more keywords