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   Articles with "zfp91" as a keyword



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Discovery of a Napabucasin PROTAC as an Effective Degrader of the E3 Ligase ZFP91.

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recommendations! Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.0c01897

Abstract: Napabucasin, undergoing multiple clinical trials, was reported to inhibit the signal transducer and transcription factor 3 (STAT3). To better elucidate its mechanism of action, we designed a napabucasin-based proteolysis targeting chimera (PROTAC), XD2-149 that resulted… read more here.

Keywords: discovery napabucasin; zfp91; xd2 149; ligase zfp91 ... See more keywords
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The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.

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recommendations! Published in 2019 at "Carcinogenesis"

DOI: 10.1093/carcin/bgz085

Abstract: The Forkhead Box A1 (FOXA1), one of the forkhead class of DNA-binding proteins, functions as a transcription factor and plays an vital role in cellular control of embryonic development and cancer progression. Downregulaton of FOXA1… read more here.

Keywords: cell survival; zfp91; cancer cell; cancer ... See more keywords

ZFP91 Regulates Multiple Myeloma Cell Proliferation through IL-1β Mediated IL-6 Secretion in the Tumor Microenvironment

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recommendations! Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-129181

Abstract: Multiple myeloma is a malignancy of terminally differentiated plasma cells that are primarily resident in the bone marrow. Despite novel therapies, myeloma remains a fatal disease. Through interactions with immune cells in the bone marrow… read more here.

Keywords: microenvironment; myeloma; zfp91; proliferation ... See more keywords
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Silencing LINC00491 Inhibits Pancreatic Cancer Progression through MiR-188-5p-induced Inhibition of ZFP91

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recommendations! Published in 2022 at "Journal of Cancer"

DOI: 10.7150/jca.65071

Abstract: Background: Pancreatic cancer is recognized as one of the most malignant tumors with poor prognosis. Recently, long noncoding RNAs (lncRNAs) are considered as a potential prognostic biomarker of PC. However, the concrete biological effect of… read more here.

Keywords: zfp91; silencing linc00491; pancreatic cancer; mir 188 ... See more keywords