Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-05526-y
Abstract: The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-κB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ZFTA’s expression profile and… read more here.
Keywords: zfta; zfta rela; expression; ependymal cells ... See more keywords
EPEN-14. MOLECULAR MARKERS AND PREDICTORS OF OUTCOME FOR PAEDIATRIC INTRACRANIAL EPENDYMOMA IN THE PROSPECTIVE, MULTICENTRE E-HIT2000 TRIAL AND SUBSEQUENT HIT-REGISTRIES: A POOLED ANALYSIS OF 244 PATIENTS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.216
Abstract: Abstract BACKGROUND Throughout the past decade, molecular tools have revolutionised ependymoma classification, yet their application has been limited in clinical trial cohorts. METHODS We present the molecular analysis of paediatric ependymoma patients from the E-HIT2000… read more here.
Keywords: analysis; trial; zfta; epn zfta ... See more keywords
EPEN-17.IN VITRO MODELLING OF PEDIATRIC SUPRATENTORIAL EPENDYMOMAS USING CEREBRAL ORGANOIDS
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DOI: 10.1093/neuonc/noae064.219
Abstract: Abstract BACKGROUND Ependymomas (EPN) are glial tumors of the central nervous system occurring in children and adults. ZFTA-fusion positive and YAP1-fusion positive EPN are the main supratentorial (ST) subgroups in children. While most ST-EPN-YAP1 patients… read more here.
Keywords: fusion; yap1; zfta; tumor ... See more keywords
EPEN-22. ZFTA FUSION ONCOPROTEINS DRIVE ONCOGENESIS THROUGH ASSEMBLY OF BIOMOLECULAR CONDENSATES
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DOI: 10.1093/neuonc/noae064.224
Abstract: Abstract BACKGROUND Ependymomas continue to be an aggressive brain tumor entity without targeted therapies. The highly recurrent fusion oncoprotein (FO), ZFTA-RELA, is known to be associated with about 70% of supratentorial ependymomas. While recent studies… read more here.
Keywords: zfta rela; fusion oncoproteins; zfta fusion; zfta ... See more keywords
TMOD-14. Synthetic ZFTA-fusions pinpoint IDR acquisition as a mechanism of brain tumor development
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1888
Abstract: Over 95% of ependymomas (EPN) that arise in the cortex are characterized by gene fusions commonly involving the zinc finger translocation associated (ZFTA) protein. These fusion oncoproteins (FOs) join ZFTA with either a transcription factor… read more here.
Keywords: zfta fos; brain; zfta; brain tumor ... See more keywords
ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1052
Abstract: ZFTA (C11orf95)-a gene of unknown function-partners with a variety of transcriptional co-activators in translocations that drive supratentorial ependymoma, a frequently lethal brain tumor. Understanding the function of ZFTA is key to developing therapies that inhibit… read more here.
Keywords: chromatin; zfta; translocations constitute; fusion proteins ... See more keywords