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   Articles with "zfta rela" as a keyword



Ependymoma associated protein Zfta is expressed in immature ependymal cells but is not essential for ependymal development in mice

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recommendations! Published in 2022 at "Scientific Reports"

DOI: 10.1038/s41598-022-05526-y

Abstract: The fusion protein of uncharacterised zinc finger translocation associated (ZFTA) and effector transcription factor of tumorigenic NF-κB signalling, RELA (ZFTA-RELA), is expressed in more than two-thirds of supratentorial ependymoma (ST-EPN-RELA), but ZFTA’s expression profile and… read more here.

Keywords: zfta; zfta rela; expression; ependymal cells ... See more keywords

EPEN-22. ZFTA FUSION ONCOPROTEINS DRIVE ONCOGENESIS THROUGH ASSEMBLY OF BIOMOLECULAR CONDENSATES

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.224

Abstract: Abstract BACKGROUND Ependymomas continue to be an aggressive brain tumor entity without targeted therapies. The highly recurrent fusion oncoprotein (FO), ZFTA-RELA, is known to be associated with about 70% of supratentorial ependymomas. While recent studies… read more here.

Keywords: zfta rela; fusion oncoproteins; zfta fusion; zfta ... See more keywords

TMET-49. ZFTA-RELA ependymomas produce macrophage-associated itaconate as an oncometabolite to epigenetically sustain pathogenic fusion expression

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recommendations! Published in 2025 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaf201.1740

Abstract: ZFTA-RELA ependymomas are malignant brain tumors that are frequently lethal. They are defined by fusions formed between the putative chromatin remodeler ZFTA and the NFκB-mediator-RELA. Through a comprehensive metabolic screen, we identified that ZFTA-RELA cells… read more here.

Keywords: rela ependymomas; rela; zfta rela; fusion ... See more keywords

ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.

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recommendations! Published in 2021 at "Cancer discovery"

DOI: 10.1158/2159-8290.cd-20-1066

Abstract: Over 60% of supratentorial (ST) ependymomas harbor a ZFTA-RELA (ZRfus) gene fusion (formerly C11orf95-RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic… read more here.

Keywords: zfta rela; rela dictates; rela; dictates oncogenic ... See more keywords

Molecular Characteristics of a ZFTA::RELA Fusion Gliosarcoma: A Case Report

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recommendations! Published in 2025 at "International Journal of Surgical Pathology"

DOI: 10.1177/10668969241311520

Abstract: The combination of ependymoma and gliosarcoma elements in the same tumor is extremely rare, and the molecular characteristics of these entities are not clear. Here, we present a rare aggressive brain tumor in a 12-year-old… read more here.

Keywords: report; zfta rela; fusion; characteristics zfta ... See more keywords