CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adf2687
Abstract: Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is known about the role of chromatin factors during this process. Here, we used an in vivo RNA interference reverse genetic… read more here.
Keywords: genome activation; gcn5; zygotic genome; zga ... See more keywords
Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency
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DOI: 10.3390/biom11060829
Abstract: Endogenous retroviruses (ERVs), previously viewed as deleterious relics of ancestral retrovirus infections, are silenced in the vast majority of cells to minimize the risk of retrotransposition. Counterintuitively, bursts of ERV transcription usually occur during maternal-to-zygotic… read more here.
Keywords: somatic cell; genome activation; zygotic genome; zga ... See more keywords
Dynamic Change of R-Loop Implicates in the Regulation of Zygotic Genome Activation in Mouse
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232214345
Abstract: In mice, zygotic genome activation (ZGA) occurs in two steps: minor ZGA at the one–cell stage and major ZGA at the two–cell stage. Regarding the regulation of gene transcription, minor ZGA is known to have… read more here.
Keywords: loop; dna; zygotic genome; zga ... See more keywords