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   Articles with "zga" as a keyword



CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity

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recommendations! Published in 2023 at "Science Advances"

DOI: 10.1126/sciadv.adf2687

Abstract: Zygotic genome activation (ZGA) is a crucial step of embryonic development. So far, little is known about the role of chromatin factors during this process. Here, we used an in vivo RNA interference reverse genetic… read more here.

Keywords: genome activation; gcn5; zygotic genome; zga ... See more keywords

Functions and Regulation of Endogenous Retrovirus Elements during Zygotic Genome Activation: Implications for Improving Somatic Cell Nuclear Transfer Efficiency

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recommendations! Published in 2021 at "Biomolecules"

DOI: 10.3390/biom11060829

Abstract: Endogenous retroviruses (ERVs), previously viewed as deleterious relics of ancestral retrovirus infections, are silenced in the vast majority of cells to minimize the risk of retrotransposition. Counterintuitively, bursts of ERV transcription usually occur during maternal-to-zygotic… read more here.

Keywords: somatic cell; genome activation; zygotic genome; zga ... See more keywords

Dynamic Change of R-Loop Implicates in the Regulation of Zygotic Genome Activation in Mouse

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232214345

Abstract: In mice, zygotic genome activation (ZGA) occurs in two steps: minor ZGA at the one–cell stage and major ZGA at the two–cell stage. Regarding the regulation of gene transcription, minor ZGA is known to have… read more here.

Keywords: loop; dna; zygotic genome; zga ... See more keywords

Dppa2 Promotes Early Embryo Development Through Regulating PDH Expression Pattern During Zygotic Genome Activation

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recommendations! Published in 2025 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms26073436

Abstract: During embryonic development, zygotic genome activation (ZGA) is a critical event that determines the rational process and the fate of embryonic cells. The tricarboxylic acid cycle (TCA cycle) provides necessary reactants and energy for biological… read more here.

Keywords: genome activation; dppa2; zga; development ... See more keywords