ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancer
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DOI: 10.1002/ijc.32922
Abstract: Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective… read more here.
Keywords: stat3; zic2; breast cancer; cancer ... See more keywords
ZIC2 in Holoprosencephaly.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-10-7311-3_14
Abstract: The ZIC2 transcription factor is one of the most commonly mutated genes in Holoprosencephaly (HPE) probands. HPE is a severe congenital defect of forebrain development which occurs when the cerebral hemispheres fail to separate during… read more here.
Keywords: zic2 holoprosencephaly; biology; zic2;
ZIC2 Is Essential for Maintenance of Latency and Is a Target of an Immediate Early Protein during Kaposi's Sarcoma-Associated Herpesvirus Lytic Reactivation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.00980-17
Abstract: ABSTRACT Bivalent histone modifications are defined as repressive and activating epigenetic marks that simultaneously decorate the same genomic region. The H3K27me3 mark silences gene expression, while the H3K4me3 mark prevents the region from becoming permanently… read more here.
Keywords: latency; kshv; zic2; reactivation ... See more keywords
Oxaliplatin-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) nanoparticles induced neuropathic pain through the pro-inflammatory effect of microglia in the spinal dorsal horn mediated by Zic2/membrane adapter protein 12
Sign Up to like & getrecommendations! Published in 2020 at "Materials Express"
DOI: 10.1166/mex.2020.1771
Abstract: The aim of this study is to investigate the effect and mechanism of oxaliplatin (OX)-loaded monomethoxy (polyethylene glycol)–poly(d, l-lactic-co-glycolic acid) (mPEG–PLGA) nanoparticles on neuropathic pain induced by pro-inflammatory action of Zic2/membrane adaptor protein 12 (DAP12)… read more here.
Keywords: spinal dorsal; dorsal horn; induced neuropathic; zic2 ... See more keywords
Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Cell International"
DOI: 10.1186/s12935-019-0977-9
Abstract: BackgroundProstate cancer (PCa) is a common disease that often occurs among older men and a frequent cause of malignancy associated death in this group. microRNA (miR)-129-5p has been identified as an essential regulator with a… read more here.
Keywords: angiogenesis; mir 129; zic2; pca ... See more keywords
The level of zinc finger of the cerebellum 2 is predictive of overall survival in clear cell renal cell carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Translational andrology and urology"
DOI: 10.21037/tau.2020.01.12
Abstract: Background The zinc finger of the cerebellum 2 (ZIC2) has been reported to function as an oncogenic transcription factor. However, the level and prognostic value of ZIC2 in patients with clear cell renal cell carcinoma… read more here.
Keywords: ccrcc; zic2 expression; zic2; cell ... See more keywords