Experiments and simulation on ZIKV NS2B-NS3 protease reveal its complex folding.
Sign Up to like & getrecommendations! Published in 2021 at "Virology"
DOI: 10.1016/j.virol.2021.01.014
Abstract: Zika virus has been identified in various body fluids such as semen, urine, saliva, cerebrospinal fluid, and vaginal secretion of an infected individual. The pH of these fluids varies from mildly acidic to mildly alkaline.… read more here.
Keywords: zikv ns2b; ns3 protease; protease; simulation zikv ... See more keywords
Characterization of an Allosteric Pocket in Zika Virus NS2B-NS3 Protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01326
Abstract: The NS2B-NS3 protease from Zika virus (ZIKV NS2B-NS3pro) cleaves the viral polyprotein, being essential for its replication and a therapeutic target. Inhibitors that target the active site of ZIKV NS2B-NS3pro have been developed, but they… read more here.
Keywords: protease; ns2b ns3pro; allosteric pocket; zikv ns2b ... See more keywords