Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
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DOI: 10.1007/s12250-021-00422-7
Abstract: Zika virus (ZIKV) infection could disrupt neurogenesis and cause microcephaly in neonates by targeting neural progenitor cells (NPCs). The tumor suppressor p53-mediated cell cycle arrest and apoptotic cell death have been suggested to be activated… read more here.
Keywords: zikv ns5; protein; p53 mediated; apoptosis ... See more keywords
NS5 Sumoylation Directs Nuclear Responses That Permit Zika Virus To Persistently Infect Human Brain Microvascular Endothelial Cells
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DOI: 10.1128/jvi.01086-20
Abstract: ZIKV is a unique neurovirulent flavivirus that persistently infects human brain microvascular endothelial cells (hBMECs), the primary barrier that restricts viral access to neuronal compartments. Here, we demonstrate that flavivirus-specific SIM and SUMO sites determine… read more here.
Keywords: sumo sites; zikv; ns5 sumo; sumo ... See more keywords
Identification of 6ω-cyclohexyl-2-(phenylamino carbonylmethylthio)pyrimidin-4(3H)-ones targeting the ZIKV NS5 RNA dependent RNA polymerase
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DOI: 10.3389/fchem.2022.1010547
Abstract: Zika virus (ZIKV), a mosquito-borne flavivirus, is a global health concern because of its association with severe neurological disorders such as neonatal microcephaly and adult Guillain-Barre syndrome. Although many efforts have been made to combat… read more here.
Keywords: rna; rdrp; activity; zikv ... See more keywords
Identification and Characterization of Zika Virus NS5 Methyltransferase Inhibitors
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DOI: 10.3389/fcimb.2021.665379
Abstract: The recurring outbreak of Zika virus (ZIKV) worldwide makes an emergent demand for novel, safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) methyltransferase (MTase), which is essential for viral replication, is regarded as… read more here.
Keywords: ns5 methyltransferase; zikv ns5; zikv; zika virus ... See more keywords