Highly sensitive determination of zileuton using TiO2 nanoparticles and the ionic liquid 1-hexylpyridinium hexafluorophosphate nanocomposite sensor
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DOI: 10.1007/s11581-018-2699-8
Abstract: The highly sensitive electrochemical determination of zileuton on a nanocomposite sensor designed by incorporation of TiO2 nanoparticles and the ionic liquid 1-hexylpyridinium hexafluorophosphate (HPFP) has been reported. The capability of the modified electrode to quantify… read more here.
Keywords: determination zileuton; nanoparticles ionic; nanocomposite sensor; highly sensitive ... See more keywords
Treatment with the 5-Lipoxygenase Antagonist Zileuton Protects Mice from Postoperative Ileus
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DOI: 10.1159/000522157
Abstract: Introduction: Previous work of our group showed that lipoxygenase (LOX) pathways become activated upon surgical manipulation of the bowel wall and revealed a beneficial immune modulating role of the LOX-derived anti-inflammatory mediator protectin DX in… read more here.
Keywords: lox; postoperative ileus; poi; role lox ... See more keywords
Inhibition of Lipoxygenases Showed No Benefit for the Musculoskeletal System in Estrogen Deficient Rats
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DOI: 10.3389/fendo.2021.706504
Abstract: Background In previous studies, we reported the beneficial impact of two lipoxygenase-inhibitors, Baicalein and Zileuton, on osteoporotic bone in a postmenopausal rat model. Whereas subcutaneous Baicalein predominantly improved cortical bone, Zileuton enhanced vertebral and femoral… read more here.
Keywords: benefit musculoskeletal; system estrogen; showed benefit; zileuton ... See more keywords
Clinical Study of Aspirin and Zileuton on Biomarkers of Tobacco-Related Carcinogenesis in Current Smokers
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DOI: 10.3390/cancers14122893
Abstract: Simple Summary Aspirin and related drugs with anti-inflammatory effects have lung cancer prevention effects in laboratory studies and through their use in populations at risk for lung cancer. We studied aspirin plus zileuton compared to… read more here.
Keywords: lung cancer; lung; aspirin plus; gene ... See more keywords
New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition
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DOI: 10.3390/molecules25204686
Abstract: A novel series of zileuton-hydroxycinnamic acid hybrids were synthesized and screened as 5-lipoxygenase (5-LO) inhibitors in stimulated HEK293 cells and polymorphonuclear leukocytes (PMNL). Zileuton’s (1) benzo[b]thiophene and hydroxyurea subunits combined with hydroxycinnamic acid esters’ ester… read more here.
Keywords: acid; zileuton hydroxycinnamic; inhibition; hydroxycinnamic acid ... See more keywords
LUNG PROTECTIVE POTENTIAL EFFECT OF ZILEUTON DURING ENDOTOXAEMIA MODEL IN MALE MICE.
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DOI: 10.36740/wlek202212130
Abstract: OBJECTIVE The aim: This study was undertaken to investigatethe possible lung protective potential effect of zileuton during polymicrobial sepsis, through modulation of inflammatory and oxidative stress pathway. PATIENTS AND METHODS Materials and methods: 24 adult… read more here.
Keywords: sepsis; lung tissue; oxidative stress; lung ... See more keywords