Cysteine Prevents the Development of Experimental Diabetes Induced by Zinc-Binding Substances
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04765-1
Abstract: In experimental rabbits, cysteine injected intravenously in a dose of 1000 mg/kg temporarily bound zinc in β cells and prevented the formation of chelate zinc complexes in response to subsequent injection of diabetogenic zinc-binding substances… read more here.
Keywords: binding substances; cysteine prevents; cysteine; zinc ... See more keywords
Interactions of zinc- and redox-signaling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101916
Abstract: Zinc and cellular oxidants such as reactive oxygen species (ROS) each participate in a multitude of physiological functions. There is considerable overlap between the affected events, including signal transduction. While there is no obvious direct… read more here.
Keywords: oxidation; zinc; zinc ros; zinc redox ... See more keywords
Inside-Out Design of Zinc-Binding Proteins with Non-Native Backbones.
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DOI: 10.1021/acs.biochem.2c00595
Abstract: The de novo design of functional proteins requires specification of tertiary structure and incorporation of molecular binding sites. Here, we develop an inside-out design strategy in the molecular modeling program Rosetta that begins with amino… read more here.
Keywords: inside design; zinc; design; binding proteins ... See more keywords
Zinc binding strength of proteins dominants zinc uptake in Caco-2 cells
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03565k
Abstract: Zinc plays a vital role in structural, catalysis, and signal regulation in the human body. Zinc deficiency leads to the dysfunction of many organs and immunity systems. Diet proteins have distinct effects on zinc uptake.… read more here.
Keywords: zinc; binding strength; zinc uptake; uptake caco ... See more keywords
Identification of Non-Zinc Binding Inhibitors of MMP-2 Through Virtual Screening and Subsequent Rescoring.
Sign Up to like & getrecommendations! Published in 2018 at "Drug research"
DOI: 10.1055/a-0586-8308
Abstract: MMP-2 belongs to a large family of proteases called matrix metalloproteinases (MMPs) that degrades type IV collagen, the main structural component of basement membranes and gelatin. The main pathologic role of MMP-2 overexpression is to… read more here.
Keywords: virtual screening; inhibitors mmp; non zinc; mmp ... See more keywords
Zinc-binding metallophores protect Pseudomonas aeruginosa from calprotectin-mediated metal starvation.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology letters"
DOI: 10.1093/femsle/fnac071
Abstract: Pseudomonas aeruginosa is known to exhibit considerable resistance to the antimicrobial activity of the metal-sequestering protein Calprotectin (CP). In this study we demonstrate that, although CP induces zinc deficiency in P. aeruginosa, a strain unable… read more here.
Keywords: binding metallophores; zinc; pseudomonas aeruginosa; calprotectin ... See more keywords
Resolving the zinc binding capacity of honey bee vitellogenin and locating its putative binding sites
Sign Up to like & getrecommendations! Published in 2022 at "Insect Molecular Biology"
DOI: 10.1111/imb.12807
Abstract: The protein vitellogenin (Vg) plays a central role in lipid transportation in most egg‐laying animals. High Vg levels correlate with stress resistance and lifespan potential in honey bees (Apis mellifera). Vg is the primary circulating… read more here.
Keywords: honey bee; honey; binding sites; zinc binding ... See more keywords
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc3207
Abstract: Interrogating zinc-binding prodrug in a 3D-reconstructed β cell environment. Advances in treating β cell loss include islet replacement therapies or increasing cell proliferation rate in type 1 and type 2 diabetes, respectively. We propose developing… read more here.
Keywords: zinc; proliferation; platform; culture ... See more keywords
Hepatitis B Virus X Protein Function Requires Zinc Binding
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Virology"
DOI: 10.1128/jvi.00250-19
Abstract: The structural maintenance of chromosomes 5/6 complex (Smc5/6) is a host restriction factor that suppresses HBV transcription. HBV counters this restriction by expressing HBV X protein (HBx), which redirects a host ubiquitin ligase to target… read more here.
Keywords: hbx function; hbx; zinc binding; hbv ... See more keywords
Effect of Enzymatic Hydrolysis on the Zinc Binding Capacity and in vitro Gastrointestinal Stability of Peptides Derived From Pumpkin (Cucurbita pepo L.) Seeds
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2021.647782
Abstract: Zinc is a crucial micronutrient for maintaining body immune system and metabolism function. However, insufficient intake from diet may lead to zinc deficiency and impair normal body function. In addition, conventional zinc salts supplementation has… read more here.
Keywords: seed; binding capacity; gastrointestinal stability; zinc ... See more keywords
Molecular Insight into the Regulation of Vimentin by Cysteine Modifications and Zinc Binding
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DOI: 10.3390/antiox10071039
Abstract: The intermediate filament protein vimentin is involved in essential cellular processes, including cell division and stress responses, as well as in the pathophysiology of cancer, pathogen infection, and autoimmunity. The vimentin network undergoes marked reorganizations… read more here.
Keywords: cysteine modifications; vimentin; cysteine; zinc binding ... See more keywords