Virtual screening and drug repositioning of FDA-approved drugs from the ZINC database to identify the potential hTERT inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1048691
Abstract: The length of the telomeres is maintained with the help of the enzyme telomerase constituting of two components, namely, a core reverse transcriptase protein (hTERT) and RNA (hTR). It serves as a significant and universal… read more here.
Keywords: approved drugs; fda approved; htert; htert inhibitors ... See more keywords
Identification of Anticancer Lead Molecules against PRR11 Protein Target with Combination of Protein Modelling Through Threading Approach, Structure Based Chemical Screening of ZINC Database and Pharmacokinetic Properties
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DOI: 10.5530/ijper.52.3.44
Abstract: PRR11 is a cell cycle regulator involved in pathogenesis of cancer. Therapeutically it has been identified as target to inhibit cancer growth. In this study, we employed in silico strategies for determining 3D structure of… read more here.
Keywords: pharmacokinetic properties; zinc database; prr11; lead molecules ... See more keywords