Reversal of Regioselectivity in Zinc‐Dependent Medium‐Chain Alcohol Dehydrogenase from Rhodococcus erythropolis toward Octanone Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000247
Abstract: The zinc‐dependent medium‐chain alcohol dehydrogenase from Rhodococcus erythropolis (ReADH) is one of the most versatile biocatalysts for the stereoselective reduction of ketones to chiral alcohols. Despite its known broad substrate scope, ReADH only accepts carbonyl… read more here.
Keywords: zinc dependent; readh w296a; octanone; readh ... See more keywords
Binding and enzymatic properties of Ageritin, a fungal ribotoxin with novel zinc-dependent function.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.125
Abstract: Ribotoxins are fungal proteins that serve as weapons against parasites and insects. They are strongly toxic due to their ability to enter host cells and inactivate ribosomes. Ageritin is the prototype of a new ribotoxin-like… read more here.
Keywords: zinc dependent; binding enzymatic; zinc; enzymatic properties ... See more keywords
Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.01.004
Abstract: Zinc-dependent histone deacetylases (HDACs) regulate the biological function of histone and non-histone proteins through the hydrolysis of acetyllysine side chains to yield free lysine and acetate. Certain HDAC isozymes exhibit alternative catalytic activities, such as… read more here.
Keywords: zinc dependent; structure mechanism; dependent histone; histone deacetylases ... See more keywords
Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00321
Abstract: The acetylation status of lysine residues on histone proteins has long been attributed to a balance struck between the catalytic activity of histone acetyl transferases and histone deacetylases (HDAC). HDACs were identified as the sole… read more here.
Keywords: zinc dependent; dependent hdacs; hdacs; biology ... See more keywords
Zinc-dependent regulation of zinc import and export genes by Zur
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15812
Abstract: In most bacteria, zinc depletion is sensed by Zur, whereas the surplus is sensed by different regulators to achieve zinc homeostasis. Here we present evidence that zinc-bound Zur not only represses genes for zinc acquisition… read more here.
Keywords: zinc concentrations; export; zinc dependent; zinc ... See more keywords
Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.
Sign Up to like & getrecommendations! Published in 2020 at "Biomedical research"
DOI: 10.2220/biomedres.41.217
Abstract: Taste-2 receptors (TAS2Rs), which belong to the G-protein coupled receptor (GPCR) family, are receptors for bitter taste perception. The aim of this study was to investigate whether zinc deficiency affects the expression of TAS2R genes.… read more here.
Keywords: promoter activity; zinc dependent; zinc; promoter ... See more keywords
TRANSCRIPTIONAL ANALYSIS OF ZINC-DEPENDENT HISTONE DEACETYLASES IN SEVERAL HUMAN CANCER CELLS.
Sign Up to like & getrecommendations! Published in 2022 at "Experimental oncology"
DOI: 10.32471/exp-oncology.2312-8852.vol-44-no-2.17983
Abstract: Histone deacetylases, especially zinc-dependent deacetylases HDACs, are among attractive drug targets for treating cancer in recent years. AIM To explore the expression level of HDACs in several human cancer cell lines and examine the possible… read more here.
Keywords: several human; histone deacetylases; human cancer; hdac ... See more keywords
Towards a Discovery of a Zinc-Dependent Phosphate Transport Road in Plants
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DOI: 10.3390/plants11223066
Abstract: Owing to the impending global scarcity of high-quality sources of phosphate (Pi) fertilizers, lowering its use in crop production requires improved insights into factors stimulating Pi uptake from the soil as well as the efficacious… read more here.
Keywords: towards discovery; discovery zinc; plants towards; dependent phosphate ... See more keywords