The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202406421
Abstract: The essential trace element, zinc, regulates virtually all aspects of cellular physiology, particularly cell proliferation and survival. Diverse families of metal transporters, metallothioneins, and metal‐responsive transcriptional regulators are linked to zinc homeostasis. However, the mechanism… read more here.
Keywords: slc30a1 plays; systemic zinc; zinc homeostasis; zinc ... See more keywords
Zinc nutrition and dietary zinc supplements.
Sign Up to like & getrecommendations! Published in 2021 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2021.1963664
Abstract: As the second most abundant trace element in the human body, zinc nutrition is constantly a hot topic. More than one-third population is suffering zinc deficiency, which results in various types of diseases or nutritional… read more here.
Keywords: zinc; zinc homeostasis; zinc supplements; nutrition ... See more keywords
Transcription factors and transporters in zinc homeostasis: lessons learned from fungi
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2020.1742092
Abstract: Abstract Zinc is an essential nutrient for all organisms because this metal serves as a critical structural or catalytic cofactor for many proteins. These zinc-dependent proteins are abundant in the cytosol as well as within… read more here.
Keywords: zinc; transcription factors; zinc homeostasis; factors transporters ... See more keywords
Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2044651
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved cellular process associated with tumorigenesis and aggressiveness, while mechanisms regulating expression of autophagic machinery genes in cancers still remain elusive. Herein, we identified E2F4 (E2F transcription factor 4) as a… read more here.
Keywords: zinc; e2f4; zinc homeostasis; cancer ... See more keywords
The changes and potential effects of zinc homeostasis in periodontitis microenvironment.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14354
Abstract: OBJECTIVES To clarify the role of zinc on periodontal health, and the potential periodontitis treatment targets based on zinc homeostasis regulation. SUBJECT Zinc is a very important and ubiquitous element, which is present in oral… read more here.
Keywords: regeneration; microenvironment; zinc; periodontitis ... See more keywords
The Two-Component System YesMN Promotes Pneumococcal Host-to-Host Transmission and Regulates Genes Involved in Zinc Homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Immunity"
DOI: 10.1128/iai.00375-22
Abstract: The ability to sense and respond rapidly to the dynamic environment of the upper respiratory tract (URT) makes Streptococcus pneumoniae (Spn) a highly successful human pathogen. Two-component systems (TCSs) of Spn sense and respond to… read more here.
Keywords: involved zinc; genes involved; two component; yesmn ... See more keywords
The Role of Zinc and Zinc Homeostasis in Macrophage Function
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/6872621
Abstract: Zinc has long been recognized as an essential trace element, playing roles in the growth and development of all living organisms. In recent decades, zinc homeostasis was also found to be important for the innate… read more here.
Keywords: zinc; macrophage function; zinc homeostasis; zinc zinc ... See more keywords
DETERMINATION OF PROTEIN TRANSPORTERS FOR THE ABSORPTION OF ZN-PEPTIDES FROM HOLOTHURIA SCABRA THROUGH NETWORK PHARMACOLOGY WITH MOLECULAR SIMULATION APPROACH
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2025v17i6.55054
Abstract: Objective: This study aimed to identify key genes and proteins involved in zinc homeostasis and to evaluate the potential of sea cucumber (Holothuria scabra) peptides as zinc-binding agents targeting the zinc transporter protein ZIP2, which… read more here.
Keywords: protein; zinc homeostasis; pharmacology; holothuria scabra ... See more keywords
Leptin Maintained Zinc Homeostasis Against Glutamate-Induced Excitotoxicity by Preventing Mitophagy-Mediated Mitochondrial Activation in HT22 Hippocampal Neuronal Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neurology"
DOI: 10.3389/fneur.2018.00322
Abstract: Developmental seizure-induced long-term neuronal hyperexcitation is partially mediated by regenerative mossy fiber sprouting in hippocampus. Yet, there are no effective drugs available to block this pathological process. Recently, leptin has been shown to prevent the… read more here.
Keywords: mitophagy mediated; glutamate induced; leptin; zinc homeostasis ... See more keywords
Zinc Transporter ZmLAZ1-4 Modulates Zinc Homeostasis on Plasma and Vacuolar Membrane in Maize
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.881055
Abstract: Zinc is an essential micronutrient for plant growth and development, and functions as a cofactor for hundreds of transcription factors and enzymes in numerous biological processes. Zinc deficiency is common abiotic stress resulting in yield… read more here.
Keywords: zinc; zmlaz1; vacuolar membrane; plasma vacuolar ... See more keywords
The Impact of Zinc and Zinc Homeostasis on the Intestinal Mucosal Barrier and Intestinal Diseases
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DOI: 10.3390/biom12070900
Abstract: Zinc is an essential trace element for living organisms, and zinc homeostasis is essential for the maintenance of the normal physiological functions of cells and organisms. The intestine is the main location for zinc absorption… read more here.
Keywords: mucosal barrier; zinc; zinc zinc; intestinal mucosal ... See more keywords