Zinc Chelator Inhibits Zinc-Induced Islet Amyloid Polypeptide Deposition and Apoptosis in INS-1 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1444-5
Abstract: Amyloid deposition and beta cell apoptosis are characteristic pathological features of type 2 diabetes mellitus (DM). Islet amyloid polypeptide (IAPP) is the most abundant component of amyloid deposition. Monomeric IAPP does not form amyloid deposition,… read more here.
Keywords: apoptosis; zinc; zinc induced; islet ... See more keywords
Characterization of the zinc-induced Shank3 interactome of mouse synaptosome.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.10.143
Abstract: Variants of the SHANK3 gene, which encodes a core scaffold protein of the postsynaptic density of excitatory synapses, have been causally associated with numerous brain disorders. Shank3 proteins directly bind zinc ions through their C-terminal… read more here.
Keywords: induced shank3; zinc; zinc induced; shank3 interactome ... See more keywords
Emodin inhibits zinc-induced neurotoxicity in neuroblastoma SH-SY5Y cells
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20182378
Abstract: Emodin is a natural anthraquinone derivative with numerous beneficial effects, including antioxidant properties, anti-tumor activities, and protecting the nerves. Zinc-induced neurotoxicity plays a crucial role in the pathogenesis of vascular dementia (VD) and Parkinson's disease… read more here.
Keywords: sy5y cells; zinc induced; induced neurotoxicity; zinc ... See more keywords
Structural basis for zinc-induced activation of a zinc uptake transcriptional regulator
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab432
Abstract: Abstract The zinc uptake regulator (Zur) is a member of the Fur (ferric uptake regulator) family transcriptional regulators that plays important roles in zinc homeostasis and virulence of bacteria. Upon zinc perception, Zur binds to… read more here.
Keywords: zinc uptake; zinc; zinc induced; xczur ... See more keywords
Iatrogenic Copper Deficiency: Risks and Cautions with Zinc Prescribing.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15749
Abstract: AIMS Copper deficiency resulting from prescribing zinc in high doses is a rare but life-changing diagnosis that is frequently overlooked. The aim of this study is to gauge how often zinc-induced copper deficiency is missed,… read more here.
Keywords: copper deficiency; copper; zinc induced; induced copper ... See more keywords
Temporal relationship of the orphan receptor TR3 translocation and expression with zinc-induced apoptosis in prostate cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Translational Andrology and Urology"
DOI: 10.21037/tau-23-61
Abstract: Background This study aimed to investigate the precise mechanism of zinc-induced apoptosis in human prostate cell lines PC-3 and LNCaP and explore its relationships with the translocation and expression of the orphan receptor TR3 and… read more here.
Keywords: apoptosis; zinc; tr3; translocation ... See more keywords
Copper as a Collaborative Partner of Zinc-Induced Neurotoxicity in the Pathogenesis of Vascular Dementia
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22147242
Abstract: Copper is an essential trace element and possesses critical roles in various brain functions. A considerable amount of copper accumulates in the synapse and is secreted in neuronal firings in a manner similar to zinc.… read more here.
Keywords: vascular dementia; zinc; pathogenesis vascular; zinc induced ... See more keywords