Zinc-Mediated Efficient and Selective Reduction of Carbonyl Compounds
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700887
Abstract: We herein describe for the first time that an optimized combination of Zn and NH4Cl can be used for the selective reduction of aldehydes and ketones to the corresponding alcohols. The aldehyde and keto groups… read more here.
Keywords: reduction; selective reduction; reduction carbonyl; mediated efficient ... See more keywords
Zinc‐mediated efficient and environmentally benign synthesis of salicylate esters
Sign Up to like & getrecommendations! Published in 2024 at "Flavour and Fragrance Journal"
DOI: 10.1002/ffj.3800
Abstract: Considerable synthetic effort has been devoted to acid‐ or base‐catalysed transesterification of alkyl salicylate with alcohol in order to synthesize salicylate esters efficiently. In this study, the transesterification of methyl salicylate with 12 different alcohols… read more here.
Keywords: salicylate; efficient environmentally; environmentally benign; salicylate esters ... See more keywords
Zinc-mediated reactions on salicylaldehyde for Botrytis cinerea control
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2019.08.053
Abstract: Abstract Botrytis cinerea is a necrotrophic fungus that affects various plant species. Chemical control is a necessity and as much as possible, eco-friendly conditions and bioresources to obtain these chemicals should be used. In this… read more here.
Keywords: mediated reactions; control; botrytis cinerea; zinc mediated ... See more keywords
Zinc mediated straightforward access to diacylpyrroles
Sign Up to like & getrecommendations! Published in 2017 at "Comptes Rendus Chimie"
DOI: 10.1016/j.crci.2017.01.003
Abstract: Abstract In this article, we report the preparation of various 2,4- and 2,5-diacylpyrroles via two zinc-mediated acylation reactions of non-protected pyrroles. read more here.
Keywords: straightforward access; mediated straightforward; access diacylpyrroles; zinc mediated ... See more keywords
Zinc-mediated anionic cyclization of unstabilized ketone enolates with unactivated alkenes
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron"
DOI: 10.1016/j.tet.2020.131417
Abstract: Abstract We report herein general conditions for a zinc-mediated anionic cyclization of unstabilized ketone enolates. This anionic cyclization allows access to various carbocyclic architectures by utilizing abundant ketones and unactivated alkenes as precursors. The transformation… read more here.
Keywords: anionic cyclization; cyclization; mediated anionic; unstabilized ketone ... See more keywords
Zinc-Mediated Hydroxyallylation of Aldehydes with Cyclopropanols: Direct Access to Vicinal anti-sec,tert-Diols via Enolized Homoenolates.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c04331
Abstract: Direct and diastereoselective synthesis of vicinal anti-sec,tert-diols has been achieved by zinc-mediated α-hydroxyallylation of aldehydes with cyclopropanols. The reaction features the action of the zinc-enolized homoenolate as a γ-oxyallyl nucleophile toward the carbonyl electrophile. The… read more here.
Keywords: anti sec; zinc mediated; sec tert; mediated hydroxyallylation ... See more keywords
Zinc-Mediated Transformation of 1,3-Diols to Cyclopropanes for Late-Stage Modification of Natural Products and Medicinal Agents
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c02362
Abstract: A method for incorporating cyclopropane motifs into complex molecules has been developed. Herein we report a zinc dust-mediated cross-electrophile coupling reaction of 1,3-dimesylates to synthesize cyclopropanes. 1,3-Dimesylates can be readily accessed from 1,3-diols, a functionality… read more here.
Keywords: medicinal agents; zinc mediated; natural products; late stage ... See more keywords
Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01866
Abstract: An efficient and mild zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters, to give monofluoroalkenes in moderate to excellent yields with high Z-selectivity is reported. The reaction tolerates a broad range of functional groups… read more here.
Keywords: mediated decarboxylative; decarboxylative alkylation; gem difluoroalkenes; alkylation gem ... See more keywords
Zinc-mediated carboxylations of allylic and propargylic halides in flow: synthesis of β-lactones via subsequent bromolactonization
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra07715a
Abstract: Zinc-mediated carboxylation of allylic halides under flow conditions delivered β,γ-unsaturated carboxylic acids and subsequent bromolactonization provides a streamlined process for the synthesis of γ-bromo-β-lactones. The described process further demonstrates the utility of organozinc reagents prepared… read more here.
Keywords: halides flow; zinc mediated; subsequent bromolactonization; synthesis ... See more keywords
CFTR is required for zinc-mediated antibacterial defense in human macrophages
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2315190121
Abstract: Significance Mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) cause CF, a disease characterized by aberrant lung function, dysregulated innate immunity, and susceptibility to infections. Combination drugs such as elexacaftor–tezacaftor–ivacaftor (ETI) restore lung… read more here.
Keywords: zinc; cftr; zinc mediated; required zinc ... See more keywords
A Simple Zinc-Mediated Method for Selenium Addition to Michael Acceptors
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25092018
Abstract: In this work, we focused our attention on seleno-Michael type reactions. These were performed using zinc-selenolates generated in situ from diphenyl diselenide 1, 1,2-bis(3-phenylpropyl)diselenide 30, and protected selenocystine 31 via an efficient biphasic Zn/HCl-based reducing… read more here.
Keywords: simple zinc; michael; addition; zinc mediated ... See more keywords