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   Articles with "zingerone" as a keyword



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Zingerone ameliorates oxidative stress and inflammation in bleomycin-induced pulmonary fibrosis: modulation of the expression of TGF-β1 and iNOS

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recommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"

DOI: 10.1007/s00210-020-01881-7

Abstract: Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with limited treatment options. Zingerone found in ginger ( Zingiber officinale L .) has many pharmacological effects, especially antiinflammatory and antioxidant activity. However, the effect of… read more here.

Keywords: zingerone; fibrosis; inflammation; tgf inos ... See more keywords
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Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines.

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recommendations! Published in 2019 at "ACS applied materials & interfaces"

DOI: 10.1021/acsami.8b14559

Abstract: We base this study on the concept of drug repositioning to reconstitute the natural product of zingerone as zingerone nanoparticles (zingerone NPs) through a one-pot synthesized process. The as-fabricated zingerone NPs were characterized; they possessed… read more here.

Keywords: zingerone; human hepatoma; cell lines; zingerone nps ... See more keywords
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Zingerone stimulates osteoblast differentiation by increasing Smad1/5/9‐mediated HO‐1 expression in MC3T3‐E1 cells and primary mouse calvarial cells

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recommendations! Published in 2022 at "Clinical and Experimental Pharmacology and Physiology"

DOI: 10.1111/1440-1681.13681

Abstract: Zingerone is a non‐volatile compound found mainly in dried ginger. Zingerone increases the expression of osteogenic markers and has antioxidant effects. A previous study showed that zingerone accelerated osteoblast differentiation by suppressing the expression of… read more here.

Keywords: osteoblast differentiation; zingerone; smad1 mediated; expression ... See more keywords
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Zingerone ameliorates non-alcoholic fatty liver disease in rats by activating AMPK.

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recommendations! Published in 2022 at "Journal of food biochemistry"

DOI: 10.1111/jfbc.14149

Abstract: This study was conducted to test the protective potential of Zingerone against a high-fat diet (HFD)-mediated non-alcoholic fatty liver disease (NAFLD) development in rats and examined in this protection is mediated modulating AMP-activated protein kinase… read more here.

Keywords: alcoholic fatty; zingerone; non alcoholic; activating ampk ... See more keywords

Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition

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recommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2022/3990607

Abstract: Neutrophils release chromatin and antimicrobial proteins to trap and kill microbes, which is termed as neutrophil extracellular trap (NET) formation. NETs play a pivotal role in host defense against infection. However, emerging evidence indicated that… read more here.

Keywords: sepsis; zingerone; inhibition; nrf2 ... See more keywords
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Trastuzumab-Mediated Cardiotoxicity and Its Preventive Intervention by Zingerone through Antioxidant and Inflammatory Pathway in Rats

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recommendations! Published in 2023 at "Journal of Personalized Medicine"

DOI: 10.3390/jpm13050750

Abstract: Trastuzumab (TZB) is a new medicine, used to treat cancers of the breast and stomach. However, the cardiotoxic potential of this drug edges out its clinical advantages. The present study was designed to find out… read more here.

Keywords: zingerone; trastuzumab mediated; mediated cardiotoxicity; cardiotoxicity ... See more keywords
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Neonatal administration of zingerone prevents the subsequent development of high dietary fructose-induced early features of nephropathy in rats.

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recommendations! Published in 2022 at "General physiology and biophysics"

DOI: 10.4149/gpb_2022008

Abstract: Excessive consumption of fructose-rich diets in early life stages increases the risk for developing nephropathy in adulthood. We investigated the potential preventive effects of neonatally administered zingerone on the development of dietary fructose-induced nephropathy. Four-day-old… read more here.

Keywords: zingerone; development; group; dietary fructose ... See more keywords

Renal protective effects of zingerone in a mouse model of sepsis

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recommendations! Published in 2019 at "BMB Reports"

DOI: 10.5483/bmbrep.2019.52.4.175

Abstract: Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess pharmacological activities such as anti-inflammatory and anti-apoptotic effects. This study was initiated to determine whether ZGR could modulate renal functional damage in… read more here.

Keywords: model sepsis; sepsis; zingerone; mouse model ... See more keywords