Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23806
Abstract: Neurodegeneration is associated with inflammation and mismanaged iron homeostasis, leading to increased concentration of non‐transferrin‐bound iron (NTBI) in the brain. NTBI can be taken up by cells expressing Zrt‐, Irt‐like protein‐14 (ZIP14), which is regulated… read more here.
Keywords: neurodegeneration; iron overload; expression; zip14 ... See more keywords
ZIP14 is degraded in response to manganese exposure
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DOI: 10.1007/s10534-019-00216-1
Abstract: Manganese (Mn) is an essential element necessary for proper development and brain function. Circulating Mn levels are regulated by hepatobiliary clearance to limit toxic levels and prevent tissue deposition. To characterize mechanisms involved in hepatocyte… read more here.
Keywords: degraded response; heparg cells; exposure; zip14 degraded ... See more keywords
Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels
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DOI: 10.1016/j.exer.2016.12.008
Abstract: Abstract Intracellular retinal iron accumulation has been implicated in the pathogenesis of age‐related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO)… read more here.
Keywords: zip8 zip14; retinal iron; zip14; iron ... See more keywords
Berberine induces ZIP14 expression and modulates zinc redistribution to protect intestinal mucosal barrier during polymicrobial sepsis.
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DOI: 10.1016/j.lfs.2019.116697
Abstract: AIMS The present study investigated if berberine might induce Zrt-Irt-like protein 14 (ZIP14) and affect zinc redistribution to protect intestinal barrier in sepsis. MAIN METHODS Rodent model of sepsis was induced by cecal ligation and… read more here.
Keywords: protect intestinal; sepsis; zinc; expression ... See more keywords
The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells
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DOI: 10.1038/s41598-019-44954-1
Abstract: Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the insulin secretory process. Zip14 (SLC39a14) is a zinc importing protein that has… read more here.
Keywords: zip14; insulin; insulin secretion; beta cell ... See more keywords
Heterogeneous Immunolocalisation of Zinc Transporters ZIP6, ZIP10 and ZIP14 in Human Normo- and Asthenozoospermic Spermatozoa
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DOI: 10.3390/cimb44080237
Abstract: Zinc (in the form of Zn2+) is necessary for male fertility. Both Zn2+ quantity and its localisation have been detected in seminal plasma and ejaculated spermatozoa, suggesting its active uptake via zinc import transporters (ZIPs).… read more here.
Keywords: zinc; zip6 zip10; zip14; localisation ... See more keywords
Long Noncoding RNA, MicroRNA, Zn Transporter Zip14 (Slc39a14) and Inflammation in Mice
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DOI: 10.3390/nu14235114
Abstract: Integration of non-coding RNAs and miRNAs with physiological processes in animals, including nutrient metabolism, is an important new focus. Twenty-three transporter proteins control cellular zinc homeostasis. The transporter Zip14 (Slc39a14) responds to proinflammatory stimuli. Using… read more here.
Keywords: enterocyte specific; transporter zip14; transporter; zip14 ... See more keywords